Biological Activity
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
Targets
EGFR | PKA | PKC | ||
7.67 μM | 9.33 μM | 25.01 μM |
In vitro | DMSO | 35 mg/mL (196.47 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 56.15 mL | 280.74 mL | 561.48 mL |
0.5 mM | 11.23 mL | 56.15 mL | 112.3 mL |
1 mM | 5.61 mL | 28.07 mL | 56.15 mL |
5 mM | 1.12 mL | 5.61 mL | 11.23 mL |
*The above data is based on the productmolecular weight 178.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10286 |
---|---|
Actions | Inhibitor |
M. Wt | 178.1 |
Formula | C9H6O4 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 486-35-1 |
Synonyms | 7,8-dihydroxycoumarin |
SMILES | C1=CC(=C(C2=C1C=CC(=O)O2)O)O |
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