Daphnetin

Catalog No.: A10286

EGFR, PKA,PKC inhibitor

Daphnetin Chemical Structure

CAS NO. 486-35-1

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.

Availability: In stock

Package Price Qty
10 mg
$50.00
25 mg
$100.00
50 mg
$180.00
100 mg
$320.00
10mM * 1mL in DMSO
$68.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
Targets
EGFR PKA PKC
7.67 μM9.33 μM25.01 μM
In vitro DMSO 35 mg/mL (196.47 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 56.15 mL 280.74 mL 561.48 mL
0.5 mM 11.23 mL 56.15 mL 112.3 mL
1 mM 5.61 mL 28.07 mL 56.15 mL
5 mM 1.12 mL 5.61 mL 11.23 mL

*The above data is based on the productmolecular weight 178.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10286
Actions Inhibitor
M. Wt 178.1
Formula C9H6O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 486-35-1
Synonyms 7,8-dihydroxycoumarin
SMILES C1=CC(=C(C2=C1C=CC(=O)O2)O)O

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