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Publications citing Adooq Products
Chemical Information
| Catalog Num | A10286 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 178.1 |
| Formula | C9H6O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 486-35-1 |
| Synonyms | 7,8-dihydroxycoumarin |
| SMILES | C1=CC(=C(C2=C1C=CC(=O)O2)O)O |
Description |
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 µM), PKA (IC50 = 9.33 µM), and PKC (IC50 = 25 µM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent. | ||||||||||
Targets |
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| Solubility (25°C)* | In vitro | DMSO | 35 mg/mL (196.47 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 56.15 mL | 280.74 mL | 561.48mL |
| 0.5 mM | 11.23 mL | 56.15 mL | 112.3 mL |
| 1 mM | 5.61 mL | 28.07 mL | 56.15 mL |
| 5 mM | 1.12 mL | 5.61 mL | 11.23 mL |
*The above data is based on the productmolecular weight 178.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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