DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery applications. The Val-Ala sequence enables selective cleavage by Cathepsin B, facilitating the release of the therapeutic payload. The incorporation of a PEG spacer enhances aqueous solubility, while the DBCO group is suitable for Click Chemistry reactions due to its reactivity. Additionally, the PNP moiety serves as an efficient leaving group, making this compound valuable in bioconjugation and therapeutic development.
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable antibody-drug conjugate (ADC) linker designed for targeted delivery applications. The Val-Ala sequence enables selective cleavage by Cathepsin B, facilitating the release of the therapeutic payload. The incorporation of a PEG spacer enhances aqueous solubility, while the DBCO group is suitable for Click Chemistry reactions due to its reactivity. Additionally, the PNP moiety serves as an efficient leaving group, making this compound valuable in bioconjugation and therapeutic development.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
