Catalog No.
Product Name
Application
Product Information
Citations
- DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.
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Drug-Linker Conjugate for ADC
DBCO-HS-PEG2-VA-PABC-SG3199 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a SG3199-based DNA small channel crosslinker combined with a cleavable linker, facilitating targeted delivery of therapeutic agents. This reagent is suitable for the synthesis of ADCs, enabling enhanced efficacy in drug-based cancer therapies and other biomedical research applications. -
Drug-linker Conjugate
DBCO-PEG3-Glu-Val-Cit-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound incorporates the potent tubulin inhibitor Monomethyl auristatin E (MMAE), facilitating targeted delivery in cancer therapeutics. Its structural features enable effective synthesis of dual-drug ADCs, enhancing cytotoxic efficacy while minimizing off-target effects. -
Bifunctional Chelating Agent
Deferoxamine-DBCO is a bifunctional chelating agent that effectively binds to radioactive metals, such as 89Zr, via its deferoxamine (DFO) structure for radiolabeling applications. Additionally, it facilitates metal-free Huisgen cycloaddition reactions with azide-containing biomolecules, including siRNA and monoclonal antibodies, through its dibenzocyclooctyne (DBCO) moiety under bioorthogonal conditions. This reagent combines robust metal-chelating capabilities with specific bioorthogonal reactivity, making it suitable for targeted radioactive imaging studies in oncology research. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-MMAE is a conjugate designed for use in antibody-drug conjugate (ADC) synthesis, incorporating a drug-linker element. The DBCO component facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. The included MMAE moiety, a potent inhibitor of tubulin polymerization derived from dolastatin 10, exhibits significant mitotic inhibition. This reagent is ideal for advancing research in targeted cancer therapies by enabling the precise delivery of cytotoxic agents to tumor cells. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-GGFG-Dxd is a drug-linker conjugate targeting antibody-drug conjugates (ADCs) with potent antitumor activity derived from the DNA topoisomerase I inhibitor Dxd. This compound utilizes a cleavable linker, DBCO-PEG4-GGFG, which enhances selective delivery of the therapeutic agent. DBCO-PEG4-GGFG-Dxd serves as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it a valuable tool in bioconjugation applications. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-Val-Cit-PAB-MMAF is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs) that combines a cleavable PEG linker with the potent tubulin polymerization inhibitor MMAF. The DBCO moiety facilitates efficient synthesis through click chemistry, specifically strain-promoted alkyne-azide cycloaddition (SPAAC), allowing for precise conjugation to azide-containing biomolecules. This reagent is essential for enhancing the therapeutic efficacy of ADCs by enabling targeted delivery of cytotoxic agents. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-MMAF is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, utilizing MMAF as a potent tubulin polymerization inhibitor. The conjugate features a cleavable linker, DBCO-PEG4, which facilitates the selective release of MMAF within target cells. DBCO-PEG4-MMAF serves as a click chemistry reagent, containing a DBCO group that efficiently engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-modified molecules, making it a valuable tool for targeted therapeutics in cancer research. -
Drug-Linker Conjugates for ADC
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound features Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, linked to a cleavable DBCO-(PEG2-VC-PAB)2 linker. The DBCO group enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted delivery of cytotoxic agents. Its application is crucial for research in cancer therapeutics, particularly in enhancing the efficacy and selectivity of ADCs. -
Drug-Linker Conjugate for ADC
DBCO-(PEG)3-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features Monomethyl auristatin E (MMAE) linked to a DBCO-(PEG)3-VC-PAB structure, facilitating targeted drug delivery in cancer research. As a click chemistry reagent, it utilizes a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable in bioconjugation applications. -
Drug-Linker Conjugate for ADC
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound combines the DBCO-PEG3-VC linker with Exatecan, a potent inhibitor of DNA topoisomerase I. Its structure facilitates targeted delivery of the cytotoxic agent to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects. Research applications include the development of ADCs for cancer treatment, providing a strategic tool for targeted therapy and molecular oncology studies. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-VA-PBD is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound utilizes the potent antitumor antibiotic Pyrrolobenzodiazepine (PBD), which is linked via a DBCO-PEG4-VA spacer. DBCO-PEG4-VA-PBD acts as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This functionality supports the development of targeted therapies for cancer treatment, enhancing the efficacy of ADCs. -
ADC Drug-Linker Conjugate
DBCO-Val-Cit-PAB-MMAE is an ADC drug-linker conjugate designed for the synthesis of antibody-drug conjugates (ADCs). It incorporates the tubulin inhibitor MMAE, which acts as a cytotoxic agent targeting rapidly dividing cells. The DBCO-Val-Cit-PAB linker features an electrophilic group, facilitating stable conjugation to antibodies and enhancing the therapeutic efficacy of ADCs in cancer research applications. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It combines the DBCO-PEG4-VC-PAB linker with the potent cytotoxin DMEA-PNU-159682, which includes active metabolites of nemorubicin. This compound leverages click chemistry, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 serves as an effective tool in targeted cancer therapy research and the development of innovative ADCs. -
Drug-Linker Conjugate for ADC
DBCO-β-Glu-PEG12-Exatecan serves as a drug-linker conjugate specifically designed for antibody-drug conjugates (ADCs). This compound acts as a potent inhibitor of topoisomerase I, effectively disrupting DNA replication and transcription processes. Its unique structure allows for targeted delivery in therapeutic applications, making it suitable for research in cancer treatment and other malignancies. This reagent provides a valuable tool for the development and optimization of ADC formulations. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VA-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It features a potent tubulin inhibitor, MMAE, linked via a cleavable moiety, DBCO-PEG4-VA-PABC, facilitating targeted delivery to cancer cells. This conjugate is suitable for the synthesis of ADCs, demonstrating potential application in targeted cancer therapies by enhancing therapeutic efficacy while minimizing systemic toxicity. -
Anticancer Agent
DBCO-PEG3-GGFG-Exatecan is a drug-linker conjugate designed for use in antibody-drug conjugate (ADC) applications. This compound features the DBCO-PEG3-GGFG linker combined with Exatecan, a potent DNA topoisomerase I inhibitor. It is engineered to enhance the targeted delivery of cytotoxic agents to cancer cells, thereby improving therapeutic efficacy. DBCO-PEG3-GGFG-Exatecan is suited for research in cancer biology and the development of novel treatment strategies. -
Drug-Linker Conjugate
DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that incorporates the potent microtubulin inhibitor DM1, designed to facilitate antibody-drug conjugate (ADC) development. DM1, a maytansinoid, targets microtubules to inhibit cancer cell proliferation while minimizing systemic toxicity. The DBCO moiety in this compound allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing biomolecules, enabling efficient conjugation for targeted delivery in cancer research applications. -
Drug-linker Conjugate for ADC
DBCO-PEG3-Glu-VC-PABC-MMAF is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). It features the tubulin inhibitor MMAF linked through a cathepsin cleavable DBCO-PEG3-Glu-VC-PABC moiety, facilitating targeted delivery of the cytotoxic agent. This compound is valuable for research applications focusing on the development of ADCs, enabling studies on efficacy, mechanism of action, and therapeutic potential in cancer treatment. -
Fluorescent Dye
Cy5-DBCO is a near-infrared fluorescent dye that features an absorption maximum at 646 nm and emission maximum at 670 nm. This compound functions as a click chemistry reagent, containing a DBCO group that readily participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is particularly useful in bioconjugation applications, facilitating the labeling of proteins and other biomolecules for imaging and tracking studies, although it is not recommended for staining intracellular components in permeabilized cells due to potential high background. -
Orange Fluorescent Dye
DBCO-Cy3 is an orange fluorescent dye derived from the Cyanine3 fluorophore, exhibiting stable fluorescence across a pH range of 4-10. It has an excitation maximum at 555 nm and an emission maximum at 580 nm, making it suitable for various fluorescence applications. DBCO-Cy3 features rapid reaction kinetics and is compatible with standard fluorescence instruments. As a click chemistry reagent, it contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling targeted labeling and imaging in biochemical research. -
Dye Reagent
DBCO-PEG12-TCO is a dual-functional click chemistry reagent featuring both DBCO and TCO moieties. The DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, while the TCO moiety is capable of engaging in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing compounds. This reagent is suitable for applications in bioconjugation, drug discovery, and the development of functionalized biomolecules in chemical biology research. -
BG-JQ1 Intermediate
BG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways. -
NIR Fluorescent Dye
Cyanine7 DBCO is a near-infrared fluorescent dye that acts as an efficient bio-orthogonal quencher. It is generated through the covalent linkage of the Cy7 fluorescent dye and the dibenzocyclooctyne (DBCO) moiety. In biochemical applications, Cyanine7 DBCO significantly decreases the fluorescence of N3-Cy5-COOH by 90% within 90 minutes, with observable signal reduction occurring as quickly as 2-5 minutes. This reagent is ideal for deep tissue imaging and advancing receptor-targeted therapeutic strategies in chemical research. -
Azide Reactive Probe
Cyanine3 DBCO hexafluorophosphate is an azide-reactive probe designed for bioconjugation applications through copper-free "click" chemistry. It enables selective and efficient labeling of azide-functionalized biomolecules, making it an invaluable tool for imaging and analyzing cellular processes. This reagent is particularly useful in studies involving bioorthogonal chemistry and can facilitate the visualization of complex biomolecular interactions. -
Azide Reaction Probe
Cyanine 5 DBCO is an azide-reactive probe that facilitates copper-free "click" reactions for the imaging of azide-labeled biomolecules. This near-infrared (NIR) fluorescent dye exhibits low toxicity and does not adversely affect the physiological functions of non-target cells. With excitation at 635 nm and emissions ranging from 650 to 700 nm, Cyanine 5 DBCO is suitable for labeling and tracking cells in both in vitro and in vivo research applications. -
Fluorescent Dye
5-TAMRA-DBCO is a fluorescent dye featuring a 5-TAMRA core conjugated to a dibenzocyclooctyne (DBCO) moiety. This compound enables efficient copper-free click chemistry reactions with azide-functionalized biomolecules, facilitating precise bioconjugation. With emission and excitation wavelengths of 541 nm and 567 nm, respectively, 5-TAMRA-DBCO is ideal for labeling proteins, peptides, and nucleic acids, making it a valuable tool for various biological imaging and analysis applications. -
Azide-Labelled Probe
Cy5 DBCO chloride is a DBCO-based probe designed for applications involving azide-labeled biomolecules. It facilitates copper-free "Click Chemistry" through strain-promoted alkyne-azide cycloaddition (SPAAC), enabling efficient imaging of azide-modified targets. This reagent is particularly valuable for studies involving bioorthogonal labeling and tracking of biomolecules in various research applications, including cellular visualization and bioimaging. -
PROTAC Linkers
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its reactive DBCO moiety. This compound engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, allowing for precise conjugation in chemical biology applications. Its utility in targeted protein degradation research makes it a valuable tool for biochemists developing innovative therapeutic strategies. -
Fluorescent Dye
TAMRA DBCO, 5-isomer is a fluorescent dye derivative of tetramethylrhodamine (TMR) featuring a dibenzocyclooctyne (DBCO) moiety. It enables rapid and efficient labeling of azide-containing biomolecules through a sterically promoted azide-alkyne cycloaddition (SPAAC) reaction, eliminating the need for copper catalysts. This compound is suitable for a wide range of applications, including the labeling of proteins, peptides, and nucleic acids, facilitating advanced studies in biochemistry and cellular imaging. -
Azide Reaction Probe
Cyanine5 DBCO hexafluorophosphate is an azide-reactive probe designed for copper-free "click" reactions, enabling the selective imaging of azide-labeled biomolecules. This near-infrared fluorescent dye exhibits low toxicity to cells, making it suitable for both in vitro and in vivo applications without compromising the physiological functions of non-target cells. Its optimal excitation and emission wavelengths (Ex=635 nm, Em=650-700 nm) facilitate efficient cellular labeling and tracking, providing valuable insights in biological research. -
ADC Linker
DBCO-PEG3-TCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), featuring a 3-unit polyethylene glycol (PEG) spacer. This reagent facilitates click chemistry through its dibenzocyclooctyne (DBCO) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized compounds. Additionally, the TCO group supports inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules, making DBCO-PEG3-TCO a versatile tool for advancing ADC development in therapeutic research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NH-Boc is a versatile PROTAC linker featuring a cleavable structure designed for the synthesis of PROTACs and antibody-drug conjugates (ADCs). This compound utilizes a DBCO moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its PEG4 spacer enhances solubility and stability, making it suitable for various biological applications in drug development and therapeutic research. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-amine is a PEG-based linker designed for use in antibody-drug conjugates (ADCs) and PROTACs. This cleavable linker facilitates the conjugation of payloads such as MMAE to antibodies, enhancing targeted delivery to cancer cells. It has demonstrated compelling biological activities, with EC50 values of 280 nM and 22 nM for DBCO-VCpAB MMAE and DBCO-TRX MMAE, respectively, in SKBR3 cells, making it a valuable tool for researchers investigating targeted therapies. -
PROTAC Linkers
DBCO-N-bis(PEG4-NHS ester) is a bifunctional polyethylene glycol (PEG) linker featuring two NHS ester groups and a dibenzocyclooctyne (DBCO) moiety. This reagent facilitates protein modification and labeling, enhancing bioconjugation applications. As a click chemistry tool, DBCO-N-bis(PEG4-NHS ester) enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable for constructing PROTAC molecules and other bioorthogonal conjugates in various biochemical research settings. -
Click Chemical Agent
DBCO-PEG24-acid is a click chemistry reagent that incorporates a dibenzocyclooctyne (DBCO) group linked to a hydrophilic polyethylene glycol (PEG) chain. This compound facilitates copper-free click reactions, leveraging the high energy associated with the DBCO moiety for efficient bioconjugation. The terminal carboxylic acid allows for the formation of stable amide bonds with primary amines in the presence of coupling agents such as EDC or HATU. It is a valuable tool in bioconjugation studies and the development of drug delivery systems. -
ADC linker
DBCO-NHS Ester 3 is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a dibenzocyclooctyne (DBCO) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. DBCO-NHS Ester 3 is utilized in various applications involving targeted drug delivery and bioconjugation strategies in chemical biology and therapeutic development. -
Click Chemistry Intermediate
DBCO-C3-Acid is a versatile Click Chemistry intermediate that serves as a key component in the development of antibody-drug conjugate (ADC) linkers. Its chemical structure facilitates efficient conjugation processes, enabling precise attachment of cytotoxic agents to antibodies. This reagent is essential for advancing research in targeted cancer therapeutics and improving drug delivery systems. -
ADC Linker
Mal-bis-PEG3-DBCO is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, functioning through the efficient coupling of DBCO and azide moieties. This reagent incorporates a 3-unit polyethylene glycol (PEG) chain, enhancing solubility and biocompatibility. Its mechanism relies on strain-promoted alkyne-azide cycloaddition (SPAAC), making it ideal for precise conjugation applications in targeted drug delivery and cancer therapeutics research. -
PROTAC Linker
TCO-PEG4-DBCO is a versatile PROTAC linker known for its ability to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds, while the TCO component allows for inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine derivatives. TCO-PEG4-DBCO finds applications in the development of antibody-drug conjugates (ADCs), enhancing the precision and efficacy of targeted therapeutics. Its unique chemical properties make it a valuable tool for researchers in chemical biology and drug development. -
ADC Linker
Mal-Sulfo-DBCO is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. Featuring a DBCO moiety, it facilitates the efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reaction with azide-containing compounds. This property makes Mal-Sulfo-DBCO valuable for precise conjugation in targeted drug delivery applications, enhancing therapeutic efficacy while minimizing off-target effects. -
Azide Compound
Hydroxy-PEG3-DBCO is a versatile click chemistry reagent featuring a DBCO moiety and a terminal hydroxyl group. This PEG-based linker enhances solubility for labeled molecules while enabling efficient reactions with various functional groups. DBCO facilitates copper-free click chemistry, making it suitable for a wide range of bioconjugation applications in chemical and biochemical research. Designed for use in laboratory research, this reagent provides a reliable tool for developing complex biological systems and materials. -
ADC/PROTAC Linker
DBCO-NHCO-PEG4-NHS ester is a versatile linker designed for use in the synthesis of PROTACs and antibody-drug conjugates (ADCs). This PEG/alkyl/ether-based compound features a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its cleavable nature enhances the functionality and targeting capabilities of therapeutic agents, making it essential for researchers involved in drug development and bioconjugation applications. -
ADC Linker
DBCO-PEG1-OH is an ADC linker designed for effective conjugation in antibody-drug conjugate (ADC) applications. This compound facilitates the synthesis of ADCs by providing a stable and efficient link between monoclonal antibodies and therapeutic agents. Its utility in ADC development supports research in targeted cancer therapies and drug delivery systems. -
ADC Linker
DBCO-PEG3-C1-acid is an efficient ADC linker designed to facilitate strain-promoted azide-alkyne click reactions. This reagent serves as a powerful tool in the development of antibody-drug conjugates, enhancing target specificity and therapeutic efficacy. Its biocompatible PEG spacer provides solubility and flexibility, making it ideal for conjugating various cytotoxic agents for targeted cancer therapy applications. -
ADC Linker
DBCO-PEG4-Val-Ala-PAB is a cleavable ADC linker that effectively targets Cathepsin B for linker cleavage. The incorporation of Val-Ala linkers facilitates the controlled release of therapeutic agents, enhancing the efficacy of antibody-drug conjugates (ADCs). The DBCO moiety enables efficient Click Chemistry reactions, while the PEG spacer enhances the aqueous solubility of the compound, making it suitable for various biochemical applications. -
ADC Linker
Mal-PEG4-bis-PEG3-DBCO is a cleavable linker designed for use in antibody-drug conjugates (ADCs), facilitating targeted delivery of therapeutics. This reagent features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, allowing for efficient conjugation. Its PEGylated structure enhances solubility and provides stability in biological applications, making it suitable for ADC development and related research endeavors. -
ADC Linker
DBCO-PEG3 acetic-EVCit-PAB is a cleavable ADC linker that features a three-unit polyethylene glycol (PEG) chain. This compound facilitates the construction of antibody-drug conjugates (ADCs) by employing click chemistry through its dibenzocyclooctyne (DBCO) moiety, which engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG3 acetic-EVCit-PAB is integral in enhancing the specificity and efficacy of therapeutic agents in targeted cancer treatments, making it a valuable tool for bioconjugation research. -
ADC Linker
DBCO-PEG4-alkyne is a non-cleavable linker designed for antibody-drug conjugates (ADCs), featuring a 4-unit polyethylene glycol (PEG) chain. This compound serves as a versatile click chemistry reagent, incorporating an alkyne functional group that enables the efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in ADC synthesis facilitates the stable conjugation of therapeutic agents, enhancing the efficacy and selectivity of targeted cancer treatments. -
ADC Linker
Bromoacetamide-PEG4-DBCO is an efficient ADC linker that facilitates the synthesis of antibody-drug conjugates. This compound features a bromoacetamide moiety for selective labeling and a DBCO group for click chemistry applications. It is ideal for enhancing the therapeutic efficacy of targeted cancer treatments by enabling stable conjugation to antibodies. This linker is suitable for a variety of research applications focused on drug delivery systems and cancer therapeutics.
