diABZI-V/C-Mal is a potent STING agonist, exhibiting an EC50 of 314 nM in TH1 dual reporter cells. This compound activates the STING pathway, leading to the subsequent activation of the IRF3 signaling pathway, which plays a critical role in immune response. Additionally, diABZI-V/C-Mal serves as a substrate for Cathepsin B, allowing for the regeneration of diABZI-NH2 through enzymatic cleavage. It is a valuable tool for research in immunology and cancer therapy.
diABZI-V/C-Mal is a potent STING agonist, exhibiting an EC50 of 314 nM in TH1 dual reporter cells. This compound activates the STING pathway, leading to the subsequent activation of the IRF3 signaling pathway, which plays a critical role in immune response. Additionally, diABZI-V/C-Mal serves as a substrate for Cathepsin B, allowing for the regeneration of diABZI-NH2 through enzymatic cleavage. It is a valuable tool for research in immunology and cancer therapy.
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