dl-Tetrandrine is a potent calcium channel blocker that inhibits voltage-dependent calcium channels, selectively blocking Ca2+ influx with an IC50 ranging from 1-10 μM. This compound exhibits significant anti-inflammatory, immunosuppressive, and anti-arrhythmic properties by preventing intracellular calcium overload. dl-Tetrandrine is of particular interest in research related to autoimmune diseases, including rheumatoid arthritis, cardiovascular disorders, and the reversal of multidrug resistance in tumor cells.
dl-Tetrandrine is a potent calcium channel blocker that inhibits voltage-dependent calcium channels, selectively blocking Ca2+ influx with an IC50 ranging from 1-10 μM. This compound exhibits significant anti-inflammatory, immunosuppressive, and anti-arrhythmic properties by preventing intracellular calcium overload. dl-Tetrandrine is of particular interest in research related to autoimmune diseases, including rheumatoid arthritis, cardiovascular disorders, and the reversal of multidrug resistance in tumor cells.
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