dl-Tetrandrine

Catalog No.: A66216
Calcium Channel Blocker
dl-Tetrandrine is a potent calcium channel blocker that inhibits voltage-dependent calcium channels, selectively blocking Ca2+ influx with an IC50 ranging from 1-10 μM. This compound exhibits significant anti-inflammatory, immunosuppressive, and anti-arrhythmic properties by preventing intracellular calcium overload. dl-Tetrandrine is of particular interest in research related to autoimmune diseases, including rheumatoid arthritis, cardiovascular disorders, and the reversal of multidrug resistance in tumor cells.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Descriptiondl-Tetrandrine is a potent calcium channel blocker that inhibits voltage-dependent calcium channels, selectively blocking Ca2+ influx with an IC50 ranging from 1-10 μM. This compound exhibits significant anti-inflammatory, immunosuppressive, and anti-arrhythmic properties by preventing intracellular calcium overload. dl-Tetrandrine is of particular interest in research related to autoimmune diseases, including rheumatoid arthritis, cardiovascular disorders, and the reversal of multidrug resistance in tumor cells.
Product Information
Catalog NumA66216
FormulaC38H42N2O6
Molecular Weight622.75
CAS Number23495-89-8
SMILESCOC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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