Nucleoside Antimetabolite/Analog

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  1. Nucleoside Analog

    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rC(Ac) is a nucleoside analog that serves as a key monomeric building block for nucleic acid synthesis. It features a unique protection group, making it suitable for various chemical modifications in the synthesis of RNA and DNA oligonucleotides. This compound is particularly useful in studies related to synthetic biology, gene therapy, and RNA interference research.
  2. Nucleoside Analog

    dCTPαS (2'-Deoxycytidine-5'-O-(1-thiotriphosphate)) is a nucleoside analog that serves as a monomeric building block for nucleic acid synthesis. This compound plays a critical role in the incorporation of modified nucleotides into DNA and RNA, facilitating research in genetic engineering, molecular cloning, and the development of nucleotide-based therapeutics. Its unique thiophosphate structure enhances stability and reactivity, making it a valuable tool for various biochemical assays and studies.
  3. Nucleoside Analog

    3'-ONH₂-dUTP is a nucleoside analog that serves as a building block for nucleic acid synthesis. It is utilized in various molecular biology applications, including the incorporation of modified nucleotides into DNA or RNA strands. Its unique chemical properties allow for enhanced stability and potential applications in genetic engineering and therapeutic development.
  4. Nucleoside Analog

    DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-phosphoramidite is a modified nucleoside analog designed for use in nucleic acid synthesis. This phosphoramidite serves as a building block for oligonucleotide formation, facilitating the incorporation of modified nucleotides into RNA and DNA sequences. Its unique structural features enhance the stability and performance of nucleic acids in various research applications, including gene expression studies and therapeutic development.
  5. Nucleoside Analog

    LNA-CTP is a nucleoside analog that acts as a structural component in the synthesis of oligonucleotides. Its incorporation into oligonucleotides enhances their stability and binding affinity to complementary strands. This makes LNA-CTP valuable for applications in molecular biology, including gene expression analysis, antisense oligonucleotide design, and gene editing research.
  6. Nucleoside Analog

    6-Chloropurine-2'-deoxyriboside is a nucleoside analog that acts as a purine derivative. It is utilized in the synthesis of nucleic acids, serving as a building block in the creation of DNA sequences. This compound has applications in molecular biology research, particularly in studies of nucleic acid metabolism and the development of antiviral therapies.
  7. Nucleoside Analog

    Rp-TTPαS is a nucleoside analog that serves as a potent monomeric raw material for nucleic acid synthesis. This compound is critical for research applications involving the production of oligonucleotides and can enhance the efficiency of nucleotide incorporation during polymerization processes. Its unique structure allows for the exploration of modified nucleic acids, facilitating studies in molecular biology and gene editing technologies.
  8. Nucleoside Analog

    N2-DMF-2'-O-Methylguanosine is a nucleoside analog that serves as a valuable monomeric raw material for nucleic acid synthesis. Its 2'-O-methyl modification enhances stability and resistance to nucleases, making it useful for various applications in molecular biology, including the construction of modified RNA and the study of RNA-protein interactions. This compound is instrumental in advancing the development of therapeutic nucleic acids and RNA-based research.
  9. Uridine Analog

    4’-α-C-Methyluridine is a uridine analog that acts on purinergic signaling pathways. It exhibits potential antiepileptic properties, making it useful for investigating anticonvulsant and anxiolytic activities. This compound may also facilitate the development of new antihypertensive agents, offering insights into cardiovascular research applications.
  10. Nucleotide Analogue

    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine is a nucleotide analogue that serves as a key building block in nucleic acid synthesis. This compound is designed to enhance the efficiency and specificity of oligonucleotide assembly, making it valuable in genetic research and therapeutic applications. Its unique structural modifications facilitate improved stability and integration into nucleic acid sequences, supporting advances in gene editing and molecular diagnostics.
  11. Purine Nucleoside Analog

    4′-Thiocytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable reagent for cancer research and therapeutic studies.
  12. Nucleoside Analog

    LNA-ATP is a nucleoside analog that serves as a vital building block in the synthesis of oligonucleotides. Its unique structure enhances the affinity and stability of nucleic acid interactions, making it valuable for applications in molecular biology, including gene editing, RNA studies, and the development of antisense oligonucleotides. Researchers utilize LNA-ATP to improve the efficacy and specificity of nucleic acid-based technologies.
  13. Nucleoside Analog

    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one is a nucleoside analog that exhibits mutagenic properties in Escherichia coli and Salmonella typhimurium. This compound induces GC to AT transitions through replication errors, contributing to its significance in mutagenesis studies. Additionally, it demonstrates stability in bacterial systems and can be detected at wavelengths exceeding 300 nm, making it a valuable tool for research related to DNA replication and mutation mechanisms.
  14. Nucleoside Analog

    3',5'-O-TIPDS-2'-spirocyclopropyl-U is a nucleoside analog specifically designed for use in nucleic acid synthesis applications. Its unique structure allows for incorporation into oligonucleotides, facilitating studies in RNA interference and gene expression regulation. This compound is valuable in the development of novel therapeutics and in exploring the functional roles of modified nucleotides in molecular biology.
  15. Thymidine Analogue

    5-Amino-2'-deoxyuridine is a thymidine analogue that serves as a substrate in various chemical reactions. It is primarily utilized in the synthesis of labeled probes for DNA microarray analysis, facilitating the study of gene expression and genomic variations. This compound is instrumental in nucleic acid research, providing a valuable tool for molecular biology applications.
  16. Nucleoside Analog

    LNA-GDP is a nucleoside analog characterized by its incorporation into oligonucleotides, enhancing their stability and affinity for complementary strands. This compound plays a crucial role in various molecular biology applications, including gene editing, antisense technology, and the design of therapeutic oligonucleotides. Its unique structural features contribute to increased resistance against enzymatic degradation, making it a valuable tool for researchers in nucleic acid chemistry.
  17. Nucleoside Analog

    3′-O-Azidomethyl-dAMP is a nucleoside analog that serves as a monomeric substrate for nucleic acid synthesis. This compound is instrumental in the preparation of modified oligonucleotides and can be utilized in various biochemical applications such as gene editing, and the development of diagnostic tools. Its unique azido group facilitates subsequent reactions in click chemistry, enhancing functionalization possibilities in molecular biology research.
  18. Nucleoside Analog

    3'-OMe-m7GMP is a nucleoside analog that serves as a vital monomeric building block in nucleic acid synthesis. Its modified structure enhances stability and incorporation into nucleic acid polymers, making it useful for studies in molecular biology and genetic engineering. This compound supports research in RNA synthesis and the development of therapeutic oligonucleotides.
  19. Nucleoside Analog

    2'-OMe-CTP is a nucleoside analog that serves as a monomer for nucleic acid synthesis. This modified nucleotide exhibits enhanced nucleotide stability and improved binding affinity, making it useful in the development of ribonucleic acid (RNA) therapeutics and diagnostic applications. Its incorporation into oligonucleotides can enhance RNA's resistance to enzymatic degradation, facilitating studies in molecular biology and genetic engineering.
  20. Nucleoside Analog

    5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) is a nucleoside analog designed for use in nucleic acid synthesis. This compound features a protective group that ensures stability and efficiency during oligonucleotide assembly. Its unique structure facilitates the incorporation of modified ribonucleotides, making it valuable for advancing research in molecular biology and genetic engineering.
  21. Nucleoside Analog

    2'-F-CDP is a nucleoside analog that serves as a key building block in the synthesis of oligonucleotides. Its fluorinated structure enhances metabolic stability and may improve the pharmacokinetic properties of RNA-based therapeutics. This compound is valuable in research applications such as oligonucleotide design and development, enabling advancements in gene therapy and RNA interference studies.
  22. Nucleoside Analog

    Im-3'-OMe-GMP is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. It demonstrates stability and incorporation in RNA and DNA processes, making it suitable for investigating cellular functions and developing therapeutics. This compound is valuable in the study of gene expression, oligonucleotide design, and other applications in nucleic acid research.
  23. Guanosine Nucleoside

    N-Acetyl-2',3'-acetyl-guanosine is a modified guanosine nucleoside that serves as a substrate for various enzymatic processes. This compound is utilized in biochemical research to study nucleoside metabolism and nucleotide synthesis. Its unique acetyl modifications enhance solubility and stability, making it suitable for exploring nucleoside interactions and applications in RNA biochemistry.
  24. Nucleoside Analog

    3'-ONH2-dGTP is a nucleoside analog that serves as a crucial monomeric substrate for nucleic acid synthesis. Its unique chemical structure allows for incorporation into DNA and RNA, facilitating studies in molecular biology, genetic engineering, and pharmacology. This reagent is instrumental for researchers exploring nucleotide modifications and their implications in various biological processes.
  25. Nucleoside Analog

    5'-O-DMTr-2'-O-(2-Aminoethyl)-5-Me-rU is a nucleoside analog that serves as a key monomer in nucleic acid synthesis. This compound can facilitate the incorporation of modified ribonucleotides into RNA, enhancing the stability and functionality of oligonucleotides. It is particularly valuable in research applications involving RNA therapeutics and the development of novel RNA-based biomolecules.
  26. Thymidine Analog

    5-(3-Azidopropyl)uridine is a thymidine analog that displays insertional activity towards replicated DNA, making it valuable in studies of DNA synthesis and cellular labeling. This compound features an azide group, allowing it to function as a click chemistry reagent. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, and also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating diverse applications in chemical biology.
  27. Nucleoside Analog

    Fluorescein-12-dUTP is a nucleoside analog that serves as a fluorescently labeled deoxyuridine triphosphate. Its primary mechanism involves incorporation into nucleic acids during DNA synthesis, facilitating the visualization of nucleic acids in various applications. This reagent is particularly valuable in molecular biology techniques such as DNA labeling, in situ hybridization, and studying gene expression.
  28. Nucleotide Analogue

    N-Acetyltryptamine α-D-Glucose-3-phosphate acts as a nucleotide analogue, facilitating the modification and stabilization of RNA through the covalent attachment of glucose nucleotides. This compound demonstrates significant potential in enhancing RNA stability, making it an invaluable tool in research applications related to cancer and infectious diseases. Its unique structure allows for exploration into novel therapeutic strategies and biomolecular interactions.
  29. Nucleoside Analog

    Rp-dATPαS is a nucleoside analog that serves as a modified building block for nucleic acid synthesis. It is specifically designed to inhibit DNA polymerase activity, making it a valuable tool in studies of nucleic acid metabolism and replication processes. Rp-dATPαS can be employed in various research applications, including the development of novel therapeutics and the exploration of antiviral strategies.
  30. Nucleoside Analog

    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rG(Pac) is a nucleoside analog designed for use in nucleic acid synthesis. This compound serves as a versatile building block for the formation of RNA sequences and other oligonucleotides. Its distinct chemical structure allows for specific modifications, enhancing the functionality and stability of synthesized nucleic acids for various research applications, including genetic studies and therapeutic development.
  31. Nucleoside Analog

    3'-O-DMTr-2'-F-dA(Bz)-5'-CE-phosphoramidite is a nucleoside analog utilized for the synthesis of modified nucleic acids. This monomeric reagent incorporates a 2'-fluoro modification, which can enhance the stability and binding affinity of oligonucleotides. It is essential for researchers focusing on the development of therapeutic oligonucleotides and the study of nucleic acid interactions.
  32. Nucleoside Analog

    2'-O-Propargyluridine is a nucleoside analog specifically designed for the synthesis of nucleic acids. Exhibiting properties that facilitate the formation of modified oligonucleotides, it serves as a versatile building block in research applications focusing on gene expression and RNA interference. Its unique structure provides potential advantages in enhancing the stability and binding affinity of nucleic acid strands.
  33. Nucleoside Analog

    5-Aminoallyluridine-5'-triphosphate is a nucleoside analog that serves as a critical monomer for nucleic acid synthesis. Its unique structure facilitates incorporation into RNA and DNA, thereby enabling the study of nucleic acid dynamics and interactions. This reagent is valuable for applications in molecular biology, including the synthesis of modified nucleotides for investigations in gene expression and cellular assays.
  34. Nucleoside Analog

    3′-O-Azidomethyl-dCTP is a nucleoside analog that serves as a building block for nucleic acid synthesis. This compound is particularly useful in the creation of modified nucleic acids and can facilitate the study of biological processes involving DNA. Its incorporation into oligonucleotides enables applications in nucleotide labeling, probing, and other molecular biology research.
  35. Nucleoside Analog

    CAP m7G(5')ppp(5')(2'OMeG) is a nucleoside analog with a crucial role in nucleic acid synthesis. This compound acts as a building block for RNA modification, enhancing stability and resistance to degradation. It is widely used in the development of RNA-based therapeutics and molecular biology applications, including the study of messenger RNA (mRNA) capping and stability.
  36. Nucleoside Analog

    DMTr-2'-O-Me-6-Deamino-6-(m-benzenepropanoic acid 2-cyanoethyl ester)-rA-3'-CE-phosphoramidite is a nucleoside analog that serves as a monomeric building block in nucleic acid synthesis. Its unique structural modifications enable enhanced incorporation into oligonucleotides, facilitating studies in gene expression and oligonucleotide therapeutics. This reagent is valuable for researchers focused on the development of custom RNA sequences and in exploring various applications in molecular biology.
  37. Nucleoside Analog

    5-Hme-UTP is a nucleoside analog that serves as a key monomer for nucleic acid synthesis. It exhibits unique incorporation properties, allowing researchers to study RNA synthesis and function. This compound is widely utilized in applications such as the development of RNA-based therapeutics and the investigation of RNA structural dynamics.
  38. Nucleoside Analog

    N,N-Dimethyl-ATP is a nucleoside analog primarily used as a monomer in nucleic acid synthesis. This compound serves as a building block in the preparation of modified nucleic acids, facilitating studies in molecular biology and biochemistry. Its structural modifications enhance stability and affinity in various applications, including enzyme assays and biological research involving nucleic acid manipulation.
  39. Nucleoside Analog

    3',5'-TIPS-N-Ac-Cytidine is a nucleoside analog designed for use in nucleic acid synthesis applications. This compound acts as a protective reagent for nucleotides, aiding in the successful assembly of oligonucleotides. It is particularly valuable in the development of modified nucleic acids for research in molecular biology and related fields.
  40. Nucleoside Analog

    (2'OMe-5'p-G)pG is a nucleoside analog that serves as a key monomer in nucleic acid synthesis. Its modified structure enhances stability and resistance to nuclease degradation, making it suitable for the development of oligonucleotides with improved pharmacological properties. This reagent is primarily utilized in various molecular biology applications, including antisense oligonucleotide design and RNA therapeutics research.
  41. Phosphonamide Acid

    2'-OMe-4'-ODMT-5'-NO2 phenoxybutyric acid is a phosphonamide acid primarily utilized in nucleic acid synthesis. This compound serves as a key intermediate for the development of modified oligonucleotides, enhancing stability and binding affinity. It is valuable for applications in molecular biology, drug development, and genetic research.
  42. Nucleoside Analog

    CTPαS (Sp isomer) is a nucleoside analog that serves as a crucial monomeric substrate for nucleic acid synthesis. This compound is particularly valuable in the study of molecular biology and genetic research, facilitating the development of oligonucleotides and other nucleic acid-based technologies. Researchers can utilize CTPαS (Sp isomer) to explore nucleotide incorporation mechanisms and investigate various biochemical pathways.
  43. Nucleoside Analog

    2′-F-UDP is a nucleoside analog that serves as a building block in the synthesis of oligonucleotides. Its structural modifications provide enhanced stability and affinity for target sequences, making it valuable in various research applications, including genetic studies, RNA structure analysis, and the development of diagnostic tools. 2′-F-UDP is particularly useful in studies aimed at understanding nucleotide interactions and enhancing the efficacy of nucleic acid-based therapeutics.
  44. Nucleoside Analog

    DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite is a nucleoside analog utilized in the synthesis of oligonucleotides. This phosphoramidite derivative features several modifications, enhancing stability and facilitating incorporation into nucleic acid sequences. It is suitable for applications in DNA and RNA synthesis, aiding in the development of therapeutics and diagnostics.
  45. Purine Nucleoside Analog

    (2R,3S,4R)-2-(Hydroxymethyl)tetrahydrothiophene-3,4-diol is characterized as a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is useful in studies focused on understanding the cellular effects of purine metabolism and the development of targeted cancer therapies.
  46. Nucleoside Analog

    3′-O-Azidomethyl-UTP is a nucleoside analog that serves as a versatile monomer for nucleic acid synthesis. Its unique azido group allows for specific modifications and incorporation into RNA strands, facilitating the study of RNA biology and the development of RNA-based therapeutics. This reagent is ideal for applications in molecular biology, including in vitro transcription and the creation of modified nucleic acid constructs.
  47. Nucleoside Analog

    DMTr-2'-O-C6-rA(Bz)-3'-CE-Phosphoramidite is a nucleoside analog designed for use in solid-phase synthesis of oligonucleotides. It serves as a phosphoramidite monomer, allowing for the incorporation of modified nucleotide units into RNA and DNA sequences. This compound is essential for advancing research in areas such as gene expression studies, antisense oligonucleotide design, and therapeutic applications involving nucleic acids.
  48. Nucleoside Analog

    5'-DMTr-LNA-N6-Bz-A is a nucleoside analog designed for incorporation into nucleic acid sequences. This monomer exhibits enhanced stability and binding affinity, making it suitable for applications in oligonucleotide synthesis and development of therapeutics. Its modified structure offers potential advantages in gene regulation and antisense therapy research.
  49. Nucleoside Analog

    3-Deoxy-1,2-O-isopropylidene-α-D-ribofuranose is a nucleoside analog that serves as a valuable building block for nucleic acid synthesis. Its structure enables the incorporation of modified sugar units into oligonucleotides, facilitating studies in molecular biology and biochemistry. This compound is essential for exploring the role of nucleoside modifications in nucleic acid stability, hybridization properties, and therapeutic applications.
  50. Nucleotide

    Cytidine, 5′-(P,P′,P′′,P′′-tetrahydrogen imidotriphosphate) is a non-hydrolyzable nucleotide that serves as a stable analog of ATP. Its primary mechanism involves the inhibition of nucleotide hydrolysis, making it suitable for studying nucleotide interactions and enzymatic activities. This reagent is valuable for research applications such as exploring nucleotide metabolism, signaling pathways, and investigating the roles of nucleotides in cellular processes.

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