DNMT1-IN-3 is a potent inhibitor of DNA methyltransferase 1 (DNMT1), exhibiting an IC50 of 0.777 μM and a KD of 0.183 μM. This compound selectively binds to the S-adenosyl-l-methionine (SAM) site on DNMT1, effectively disrupting its methylation activity. DNMT1-IN-3 demonstrates significant biological activity by inhibiting cell proliferation in K562 cells, primarily through the induction of apoptosis and cell cycle arrest in the G0/G1 phase. Its properties make it a valuable tool for research in hematologic tumors and epigenetic regulation.
DNMT1-IN-3 is a potent inhibitor of DNA methyltransferase 1 (DNMT1), exhibiting an IC50 of 0.777 μM and a KD of 0.183 μM. This compound selectively binds to the S-adenosyl-l-methionine (SAM) site on DNMT1, effectively disrupting its methylation activity. DNMT1-IN-3 demonstrates significant biological activity by inhibiting cell proliferation in K562 cells, primarily through the induction of apoptosis and cell cycle arrest in the G0/G1 phase. Its properties make it a valuable tool for research in hematologic tumors and epigenetic regulation.
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