Droxinostat

Catalog No.: A10337

HDAC inhibitor

Droxinostat

Droxinostat Chemical Structure

CAS NO. 99873-43-5

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $32.00

10 mg

Regular Price: $70.00

Special Price $56.00

50 mg

Regular Price: $320.00

Special Price $256.00

100 mg

Regular Price: $580.00

Special Price $464.00

10mM * 1mL in DMSO

Regular Price: $78.00

Special Price $62.40

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Biological Activity

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.
Targets
Target Value
HDAC8IC50: 1.46μM
HDAC6IC50: 2.47μM
HDAC3IC50: 16.9μM
HDAC9IC50: >20μM
HDAC10IC50: >20μM
HDAC1IC50: >20μM
HDAC2IC50: >20μM
HDAC4IC50: >20μM
HDAC5IC50: >20μM
HDAC7IC50: >20μM
In vitro (25°C) DMSO 47 mg/mL (192.86 mM)
Water Insoluble
Ethanol 47 mg/mL (192.86 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 41.03 mL 205.17 mL 410.34 mL
0.5 mM 8.21 mL 41.03 mL 82.07 mL
1 mM 4.1 mL 20.52 mL 41.03 mL
5 mM 0.82 mL 4.1 mL 8.21 mL

*The above data is based on the productmolecular weight 243.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10337
Actions Inhibitor
CAS No. 99873-43-5
Formula C11H14ClNO3
M. Wt 243.7
Purity >98%
SMILES CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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