Dutasteride (Avodart)

Catalog No.: A10338

dual 5alpha-reductase inhibitor

Dutasteride (Avodart)

Dutasteride (Avodart) Chemical Structure

CAS NO. 164656-23-9

Dutasteride is a dual 5-a reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).

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10 mg

Regular Price: $40.00

Special Price $32.00

50 mg

Regular Price: $100.00

Special Price $80.00

100 mg

Regular Price: $150.00

Special Price $120.00

10mM * 1mL in DMSO

Regular Price: $50.00

Special Price $40.00

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  • Makoto Ishikawa, .et al. Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model, Sci Rep, 2018, 8: 12851 PMID: 30150786
  • Makoto Ishikawa, .et al. TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model, Neuropharmacology, 2016, Dec; 111: 142-159 PMID: 27596950
  • Makoto Ishikawa, .et al. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model, Invest Ophthalmol Vis Sci., 2014, 55(12): 8531-8541 PMID: 25406290

Biological Activity

Dutasteride is a dual 5-a reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).
Targets
5-α reductase
In vitro (25°C) DMSO 57 mg/mL (107.84 mM)
Water Insoluble
Ethanol 6 mg/mL (11.35 mM)
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.92 mL 94.61 mL 189.21 mL
0.5 mM 3.78 mL 18.92 mL 37.84 mL
1 mM 1.89 mL 9.46 mL 18.92 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 528.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10338
Actions Inhibitor
CAS No. 164656-23-9
Formula C27H30F6N2O2
M. Wt 528.5
Purity >98%
Synonyms Avodart
SMILES C[[email protected]]12CC[[email protected]]3[[email protected]]([[email protected]@H]1CC[[email protected]@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[[email protected]@H]5[[email protected]@]3(C=CC(=O)N5)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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