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- Jason J McDougall, .et al. Intracellular versus extracellular inhibition of calpain I causes differential effects on pain in a rat model of joint inflammation, Mol Pain, 2021, 17 PMID: 34006144
- Paudel DB, .et al. Expression and antiviral function of ARGONAUTE 2 in Nicotiana benthamiana plants infected with two isolates of tomato ringspot virus with varying degrees of virulence, Virology, 2018, Nov;524:127-139 PMID: 30195250
Biological Activity
E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.
Targets
| Cysteine protease | ||||
| In vitro (25°C) | DMSO | 67 mg/mL (195.66 mM) | |
| Water | Insoluble | ||
| Ethanol | 67 mg/mL | ||
| In vivo | 2% DMSO+corn oil | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.2 mL | 146.02 mL | 292.03 mL |
| 0.5 mM | 5.84 mL | 29.2 mL | 58.41 mL |
| 1 mM | 2.92 mL | 14.6 mL | 29.2 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
*The above data is based on the productmolecular weight 342.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13259 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 88321-09-9 |
| Formula | C17H30N2O5 |
| M. Wt | 342.43 |
| Purity | >98% |
| Synonyms | E-64d, E64d |
| SMILES | CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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