Catalog No.
Product Name
Application
Product Information
Citations
-
Cathepsin K Inhibitor
Odanacatib is an inhibitor of cathepsin K,an enzyme involved in bone resorption. -
Cathepsin Inhibitor
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. -
Cathepsin B inhibitor
CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.- Tianming Qiu, .et al. , Cell Death Dis, 2018, Oct; 9(10): 946 PMID: 30237538
-
Cysteine Protease inhibitor
Loxistatin Acid, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. -
Cysteine Protease inhibitor
E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.- Montserrat Llanses Martinez, .et al. , PLoS Biol, 2024, Dec 12;22(12):e3002930 PMID: 39666682
- Montserrat Llanses Martinez, .et al. , bioRxiv, 2024, January 14
- Jason J McDougall, .et al. , Mol Pain, 2021, 17 PMID: 34006144
- Paudel DB, .et al. , Virology, 2018, Nov;524:127-139 PMID: 30195250
-
cathepsin S inhibitor
Petesicatib is a cathepsin S inhibitor, used in research of immune diseases. -
Cathepsin S inhibitor
Z-FL-COCHO (LY3000328) is a novel Cathepsin S inhibitor.
- Gil-Im Mun, .et al. , Biochim Biophys Acta Mol Basis Dis, 2024, Sep 25;1871(1):167523 PMID: 39332782
- Fu R, .et al. , Sci Rep, 2020, Jan 29;10(1):1455 PMID: 31996771
- Klinngam W, .et al. , Sci Rep, 2019, Jul 2;9(1):9559 PMID: 31267034
- Chen CY, .et al. , Clin Sci (Lond), 2018, Oct 29;132(20):2221-2239 PMID: 30287519
-
Cathepsin B inhibitor
CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.- Qian Chu, .et al. , Food Chem Toxicol, 2021, Jan;147:111867 PMID: 33217525
- Ye Tao, .et al. , Chemosphere, 2020, Mar;242:124959 PMID: 31669990
- Ming Sun, .et al. , J Agric Food Chem, 2018, Nov 21;66(46):12376-12384 PMID: 30392375
- Xueyan Wu, .et al. , Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546
-
cathepsin C substrate
Gly-Phe-beta-naphthylamide is a cathepsin C substrate. The compound is described to accumulate inside lysosomes leading to their destruction. -
Cysteine Protease inhibitor
Leupeptin hemisulfate is a reversible inhibitor of trypsin-like and cysteine proteases such as calpain. -
Calpain inhibitor
PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 uM for μ-Calpain, about 20-fold selectivity over m-calpain. -
Calpain Inhibitor
Calpain Inhibitor II, ALLM is a cell-permeable inhibitor of calpain I, calpain II, cathepsin L and cathepsin B with Ki values of 120 nM, 230 nM, 0.6 nM and 100 nM, respectively. -
Selective calpain inhibitor
Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. -
Calpain Inhibitor III
MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.- Barker BS, .et al. , Neuroscience, 2019, Nov 26. pii: S0306-4522(19)30796-1 PMID: 31783100
-
Non-peptide calpain inhibitor
PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.- Hisamatsu Y, .et al. , Bioconjug Chem, 2017, Feb 15;28(2):507-523 PMID: 28032992
-
Human cathepsin L inhibitor
SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G. -
Cysteine protease inhibitor
(S,S)-Z-FA-FMK is an irreversible inhibitor of cysteine protease
-
Calpain activator
Isovalerylcarnitine is a product of the catabolism of L-leucine. It increases calpain activity. -
cysteine protease inhibitor
Cysteine Protease inhibitor is an inhibitor of cysteine protease. -
cathepsin inhibitor
VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.- Laura Odongo, .et al. , Microbiol Spectr, 2023, Sep 20;11(5):e0190823 PMID: 37728342
-
human cathepsin L inhibitor
Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. - Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity.
- Papain is a cysteine protease belonging to the peptidase C1 family, derived from the latex of the papaya (*Carica papaya*). It is widely used across various industries, including food processing (as a meat tenderizer), pharmaceuticals (for wound debridement and anti-inflammatory formulations), textiles (for fabric treatment), and cosmetics (for exfoliation and skin care products).
-
Cathepsin L inhibitor
Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of cathepsin L (CTSL), a lysosomal cysteine protease involved in protein degradation and various pathological processes. It is commonly used as a tool compound in studies of CTSL-related functions and diseases. -
Cysteine Residues Modifier
N-Ethylmaleimide (NEM) is a potent chemical reagent that irreversibly alkylates free sulfhydryl groups, specifically targeting cysteine residues. This compound serves as an effective inhibitor of cysteine proteases and significantly affects phosphate transport in mitochondria. With an IC50 value of 6.3 μM, N-Ethylmaleimide is valuable for modifying cysteine residues in proteins and peptides, making it an essential tool in biochemical research and studies involving protein functionality and structure. -
Calpain/Apoptosis Inhibitor
AK 295 is a selective calpain inhibitor that modulates apoptosis via a calpain-dependent mechanism. This compound exhibits potent neuroprotective effects and is effective in decreasing myocardial injury by inhibiting calpain activity. AK 295 is suitable for research applications related to infection, inflammation, and a variety of diseases, including cardiovascular conditions and neurological disorders such as stroke and viral myocarditis. -
Calpain Inhibitor
Z-LLY-FMK is a potent calpain inhibitor that exhibits significant effects on apoptosis across various cell systems. By inhibiting calpain activity, Z-LLY-FMK has been shown to mitigate intestinal apoptosis following common bile duct ligation and reduce parasite burden in mouse models challenged with Taenia crassiceps cysts. This reagent serves as a valuable tool for research into cysticercosis and the role of calpain in cellular processes. -
Calpain/Cathepsin Inhibitor
ALLM, also known as Calpain inhibitor II, acts as a potent inhibitor of calpain and cathepsin proteases. This compound is known to mitigate neuronal cell death, thereby enhancing chronic neurological function following spinal cord injury (SCI). Its utility in research extends to studies investigating protease activity and the mechanisms underlying neuroprotection in trauma-related conditions. -
Calpain Inhibitor
(Rac)-Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor that selectively modulates calpain activity, implicated in neurodegenerative processes. This compound is designed for research applications focused on neurodegeneration, providing a valuable tool for investigating the role of calpain in cellular function and injury. The inhibition of calpain activity may contribute to understanding the molecular mechanisms underlying neurodegenerative disorders. -
Calpain Inhibitor
Calpain Inhibitor V (Mu-Val-HPh-FMK) is an irreversible inhibitor of calpain, designed for effective cellular penetration. This compound exhibits notable anti-chlamydial activity and is utilized in research exploring calpain-mediated pathways and their implications in various diseases. Its application extends to studies focused on cellular signaling processes and the therapeutic potential of calpain modulation. -
μ-Calpain Inhibitor
Calpain Inhibitor-2 is a peptide inhibitor targeting μ-calpain, with a Ki value of 9 nM. This compound demonstrates significant antiproliferative activity against melanoma cell lines, specifically A-375 and B-16F1, as well as PC-3 prostate cancer cells in vitro. It is a valuable tool for research applications focused on exploring calpain-mediated pathways in cancer biology.
