Echinoside A is a saponin that primarily targets Topoisomerase II alpha (Top2α), inhibiting its catalytic activity and reducing its noncovalent binding to DNA. This compound activates Caspase-3 and induces PARP cleavage, thereby promoting apoptosis. Echinoside A exhibits significant anticancer properties against various cancers, including prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Additionally, it displays antifungal activity across a spectrum of fungi, with a minimum inhibitory concentration ranging from 3.12 to 50.0 μg/mL, demonstrating particularly strong effects against Aspergillus and Penicillium species.
Echinoside A is a saponin that primarily targets Topoisomerase II alpha (Top2α), inhibiting its catalytic activity and reducing its noncovalent binding to DNA. This compound activates Caspase-3 and induces PARP cleavage, thereby promoting apoptosis. Echinoside A exhibits significant anticancer properties against various cancers, including prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Additionally, it displays antifungal activity across a spectrum of fungi, with a minimum inhibitory concentration ranging from 3.12 to 50.0 μg/mL, demonstrating particularly strong effects against Aspergillus and Penicillium species.
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