Catalog No.
Product Name
Application
Product Information
Citations
-
Antifungal compound
Amorolfine hydrochloride, is a morpholine antifungal reagent that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. -
imidazole antifungal agent
Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis. -
Azole antifungal agent
Isavuconazole is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata. -
antifungal agent
Propylparaben is an antifungal agent.- Jingyeong Shin, .et al. , Chemical Engineering Journal, 2023, December
-
antifungal
(L)-alpha-Terpineol is a monoterpene alcohol. It is one of the components responsible for the antifungal activity of Melaleuca alternifolia (tea tree) essential oil. α-Terpineol may be used in the synthesis of α-terpinyl esters of acetic acid and acetic anhydride via lipase-mediated esterification. -
fungal inhibitor
Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL. -
fungal Cyp51 inhibitor
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes. -
antifungal drug
Chlordantoin is an antifungal drug which can be used to treat vaginal candidiasis. -
antifungal
The compound 7,4'-Di-O-methylapigenin may be partly responsible for the reported antifungal activity of C. zeyheri, and may serve as a potential source of lead compounds that can be developed as antifungal phytomedicines. -
Antifungal Agent
Isavuconazonium sulfate (BAL8557-002) is an orally active, broad-spectrum antifungal prodrug that is rapidly hydrolyzed in vivo to yield the active triazole compound **Isavuconazole**. It exhibits potent antifungal activity by inhibiting lanosterol 14α-demethylase, a key enzyme in the ergosterol biosynthesis pathway, thereby disrupting fungal cell membrane integrity. Isavuconazonium sulfate is effective against a wide range of pathogenic fungi, including *Aspergillus* and *Mucorales* species, and is used in the study and treatment of invasive aspergillosis, mucormycosis, blastomycosis, and *Acanthamoeba* keratitis. Its excellent oral bioavailability and favorable safety profile make it a valuable therapeutic and research tool in antifungal pharmacology. -
Glucosinolate
Sinigrin, a glucosinolate primarily found in cruciferous vegetables, exhibits significant biological activities including anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, along with the inhibition of fat synthesis. This compound is of particular interest in cancer research, as well as studies focused on inflammatory and metabolic diseases. Its diverse therapeutic potential makes it a valuable reagent for exploring various biological pathways. -
Fungicide
Pyraclostrobin is a strobilurin fungicide that functions by inhibiting mitochondrial respiration in fungi. It exhibits broad-spectrum antifungal activity, effectively controlling various crop diseases. Additionally, Pyraclostrobin has been shown to induce oxidative DNA damage and activate AMPK/mTOR signaling pathways, leading to mitochondrial dysfunction and autophagy. Its applications extend to agricultural settings for the management of fungal pathogens. -
Short-chain Fatty Acid
Magnesium acetate tetrahydrate acts primarily as a short-chain fatty acid (SCFA). It is known to activate AMP-activated protein kinase (AMPK) and increase reactive oxygen species (ROS) levels, leading to the cleavage of caspase 9 and the modulation of peroxisome proliferator-activated receptor alpha (PPARα). Additionally, it downregulates the expression of sterol regulatory element-binding protein 1c (SREBP-1c) and carbohydrate response element-binding protein (ChREBP), and demonstrates antifungal activity against Saccharomyces cerevisiae. Magnesium acetate tetrahydrate has shown promising anticancer effects in gastric cancer and may regulate energy metabolism while exhibiting potential therapeutic effects in ulcerative colitis and hepatic steatosis. -
Large Cyclic Mucor Toxin.
Satratoxin G is a large cyclic mucor toxin that primarily induces apoptosis through the activation of caspases. This compound exhibits potent biological activity, making it a valuable tool for studying apoptosis and cell signaling pathways. Satratoxin G is commonly utilized in research concerning fungal toxins and their effects on mammalian cells, providing insights into potential therapeutic interventions for toxin-related diseases. -
Microbial Metabolite
Oosporein is a microbial metabolite characterized as a red crystalline toxin produced by various fungi. It demonstrates significant biological activity by inhibiting insect immunity, thereby promoting fungal reproduction within host organisms. Additionally, Oosporein exhibits antibacterial, antiviral (specifically against herpes simplex virus), and insecticidal properties. Its effects on plant growth inhibition and its ability to induce apoptosis, cell membrane damage, oxidative stress, and mitochondrial damage make it a valuable compound for research in multiple fields, including mycology, agriculture, and oncology. -
Glucosinolate
Sinigrin hydrate is an allyl-glucosinolate known for its diverse biological activities, primarily targeting glucosinolate pathways. This compound exhibits anti-cancer, antibacterial, antifungal, anti-inflammatory, and antioxidant properties, as well as the ability to inhibit fat synthesis. Sinigrin hydrate is valuable for research into tumor biology, inflammatory processes, and metabolic disorders. -
Furofuran Type Lignan
(+)-Medioresinol is a furofuran-type lignan that exhibits notable antifungal and antibacterial activities. It enhances the efficacy of antibiotics through its antimicrobial and antibiofilm properties and promotes intracellular reactive oxygen species (ROS) accumulation, leading to mitochondrial-mediated apoptosis in Candida albicans. Additionally, (+)-Medioresinol inhibits LPS-stimulated IL-12p40 production and acts as a PGC-1α activator, providing protection against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. This compound is valuable for research into fungal and bacterial infections, inflammatory responses, and ischemic stroke mechanisms. -
Fungicide
Triadimefon is an orally active fungicide targeting various fungal species. It has been shown to significantly reduce the phosphorylation of AKT1 and ERK1/2, while increasing levels of phosphorylated AMPK without affecting total AMPK levels. Triadimefon inhibits the growth of Saccharomyces cerevisiae, disrupts hormone homeostasis impacting testosterone synthesis, and affects fetal adrenal development in rodent models. Additionally, it induces metabolic alterations in hepatocytes and impairs spatial learning and memory. -
Iron Chelator
Desferricoprogen is a hydrophobic fungal iron chelator that targets iron metabolism. It has been shown to reduce atherosclerotic plaque formation and inhibit lipid peroxidation in the aortic roots of ApoE−/− mice on an atherogenic diet. Additionally, Desferricoprogen effectively lowers levels of oxidized LDL (oxLDL) and inhibits the expression of oxLDL-induced genes such as HO-1, CD36, and TNF-α. Furthermore, it prevents TNF-α-induced endothelial cell activation and maintains endothelial monolayer integrity, making it a valuable tool for research on atherosclerosis. -
Antifungal Agent
Fluconazole is a triazole antifungal agent that primarily targets fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It exhibits potent activity against a wide spectrum of fungi, particularly Candida albicans and Candida kefyr, with IC99 values ranging from 0.20 μg/mL to 0.39 μg/mL. Fluconazole is widely utilized in research to study fungal pathogenesis and develop therapeutic strategies against fungal infections. -
Antifungal Agent
Miconazole is an imidazole antifungal agent that acts through the inhibition of ergosterol synthesis, disrupting fungal cell membrane integrity. In addition to its antifungal properties, Miconazole exhibits antibacterial effects, making it a versatile compound in microbiological studies. This reagent is commonly utilized in research focusing on antifungal therapies and mechanisms of microbial resistance. -
Antifungal Agent
Miconazole nitrate is an imidazole antifungal agent that exhibits its primary mechanism through the inhibition of ergosterol synthesis, leading to compromised fungal membrane integrity. This compound demonstrates significant antifungal activity against a broad spectrum of fungi, making it valuable for research in antifungal drug development and therapeutic applications. Additionally, Miconazole nitrate possesses antibacterial properties, contributing to its utility in studies related to infections and microbial resistance. -
Antimicrobial Agent
Terbinafine is a potent antimicrobial agent that primarily acts as a non-competitive inhibitor of squalene epoxidase, exhibiting a Ki of 30 nM against Candida species. This compound demonstrates significant antifungal activity and also shows antibacterial effects against select Gram-positive and Gram-negative bacteria. Additionally, Terbinafine features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for versatile chemical applications in research. -
Antifungal Agent
Oxiconazole nitrate is a broad-spectrum antifungal agent targeting various fungal pathogens, including Candida, Aspergillus, and Trichophyton. In addition to its antifungal properties, it acts as a potent activator of CYP3A4 transactivation, with the potential for competitive antagonism by Rifampicin. Furthermore, Oxiconazole nitrate exhibits inhibitory effects against colorectal cancer through mechanisms involving peroxiredoxin-2 (PRDX2)-mediated autophagy arrest, making it valuable for research in both antifungal therapy and cancer biology. -
Squalene Epoxidase Inhibitor
Liranaftate is a potent squalene epoxidase inhibitor exhibiting anti-fungal properties. It is primarily utilized in research focusing on dermatophyte infections. Additionally, Liranaftate has been shown to suppress the fungal element-mediated production of interleukin-8 (IL-8) and modulate inflammatory responses, making it valuable for studies involving inflammatory pathways in fungal infections. -
Antifungal Agent
Gartanin is a natural xanthone derived from mangosteen, primarily functioning as an antifungal agent. It exhibits significant antioxidant and anti-inflammatory properties, alongside neuroprotective and antineoplastic effects. Gartanin has been shown to induce cell cycle arrest and autophagy, while also inhibiting migration in human glioma cells, making it a valuable compound for research in cancer and fungal pathologies. -
Fungal Inhibitor
Pseudolaric Acid C is a bioactive diterpenoid derived from the root bark of Pseudolarix amabilis, primarily acting as a fungal inhibitor. It exhibits significant antifungal activity, making it a valuable tool for research focused on fungal pathogenesis and the development of antifungal therapies. Its ability to disrupt fungal growth positions it as an important compound in the study of mycology and related fields. -
Fungal Inhibitor
5-Hydroxymethylfurfural is a furan derivative that serves as a potent fungal inhibitor. It exhibits anti-yeast activity by suppressing growth and fermentation under stress conditions, making it valuable for studies related to microbial resistance and fermentation processes. This compound is utilized in research focused on food preservation and biotechnological applications. -
Bactericidal Agent
Terpinen-4-ol, a naturally occurring monoterpene, acts primarily as a bactericidal agent. This compound exhibits significant antifungal, anti-inflammatory, and antitumor activities, making it a valuable tool for diverse research applications, especially in the study of microbial resistance and inflammation. Its multiple biological effects also support investigations into potential therapeutic uses in various diseases. -
Bicyclic Sesquiterpene
Caryophyllene oxide is a bicyclic sesquiterpene known for its anticancer properties, particularly its ability to induce apoptosis in PC-3 prostate cancer cells. This compound also exhibits significant analgesic and anti-inflammatory activities, making it valuable for pain management research. Additionally, caryophyllene oxide demonstrates a range of biological activities, including insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic effects, supporting its utility in various pharmacological studies and natural product research. -
Anti-Fungal Agent
Hypocrellin B is a photosensitizer with significant apoptotic properties, primarily used in photodynamic therapy for cancer treatment. Isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, it exhibits both antimicrobial and antileishmanial activities. This compound is valuable in research exploring its efficacy against various fungal infections and its potential therapeutic applications in oncology. -
Antifungal Agent
4-Methylcinnamic acid is a cinnamic acid derivative primarily known for its antifungal properties. This compound demonstrates the capability to enhance the efficacy of traditional antifungal agents by lowering their minimum inhibitory concentrations, particularly in the presence of glutathione reductase mutants. Its mechanism includes disrupting fungal cell walls, making it a promising candidate for research into combating drug-resistant fungi. 4-Methylcinnamic acid shows potential applications in the development of more effective antifungal therapies. -
Antifungal Agent
Vincetoxicoside B is an antifungal agent that exhibits potent activity against various fungal pathogens. This compound can be utilized in research focused on fungal infections and the development of new therapeutic strategies. Its mechanism of action and efficacy make it a valuable tool in the study of antifungal mechanisms and resistance. -
Fungal Inhibitor
Hecogenin is a steroid saponin derived from Agave sisalana, known for its selective inhibition of human UDP-glucuronosyltransferases. It exhibits a diverse range of biological activities, particularly as a potent antifungal agent, while also demonstrating anti-inflammatory and gastroprotective properties. Hecogenin is of interest in pharmacological research for its potential therapeutic applications in treating fungal infections and inflammatory conditions. -
Cytochrome P450 1A1 Inactivator
Rhapontigenin is a potent and selective inactivator of cytochrome P450 1A1, demonstrating an IC50 of 400 nM. This natural analog of resveratrol exhibits significant anticancer, antioxidant, antifungal, and antibacterial properties. Due to its 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively, Rhapontigenin is a valuable tool for research focused on cancer biology and drug metabolism. -
Antifungal Agent
Xanthoxylin, an antifungal agent derived from Zanthoxylum simulans, exhibits notable antifungal and antioxidant properties. It demonstrates minimum inhibitory concentrations (MIC) of 50 µg/mL against Toxoplasma neonatorum and 75 µg/mL against Aspergillus fumigatus. This compound is valuable for investigating antifungal therapies and exploring potential applications in the context of anti-epileptic diseases. -
Antibacterial/Antifungal agent
Dehydroacetic acid is a pyrone derivative known for its antibacterial and antifungal properties. This compound exhibits significant phytotoxic activity, making it a valuable agent in various applications such as preservation in cosmetics, food, and beverages. Additionally, dehydroacetic acid serves as a precursor in the synthesis of various heterocycles and cycloaddition products, providing utility in chemical research and development. -
Antifungal Agent
Sertaconazole nitrate is a broad-spectrum topical antifungal agent that primarily targets fungal infections. In addition to its antifungal properties, it exhibits anti-inflammatory activity through the activation of the p38-COX-2-PGE2 pathway. Sertaconazole nitrate also acts as a microtubule inhibitor, demonstrating antiproliferative effects, as well as the ability to induce apoptosis and autophagy. Furthermore, it can inhibit cell migration, making it valuable for various research applications in mycology and cellular biology. -
Antifungal Agent
Sulconazole mononitrate is an imidazole derivative that acts as a broad-spectrum antifungal agent. It exhibits significant efficacy against various fungal infections, making it useful for research related to dermatomycoses, pityriasis versicolor, and cutaneous candidiasis. This compound can facilitate studies aimed at understanding the mechanisms of fungal resistance and the development of effective treatment options. -
Antimicrobial Agent
Mafenide Acetate is a potent sulfonamide antimicrobial agent primarily targeting bacterial infections. It exhibits significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, as well as antifungal activity against filamentous fungi, including Lichtheimia and Aspergillus flavus. This compound is valuable in research applications related to skin grafts on burn wounds, post-traumatic invasive fungal infections, and the treatment of bacterially contaminated wounds. -
Antifungal Agent
10-Undecenoic acid zinc salt is an antifungal agent that targets various fungal pathogens. It demonstrates biological activity by inhibiting Aβ oligomerization, scavenging reactive oxygen species (ROS), and inhibiting μ-calpain activity, contributing to its neuroprotective properties. Additionally, this compound has anticancer effects against multiple tumor types and effectively inhibits biofilm formation by C. albicans as well as infections from MRSA. Furthermore, 10-Undecenoic acid zinc salt disrupts quorum sensing signals in Bacillus subtilis and Pseudomonas aeruginosa, highlighting its broad-spectrum antimicrobial potential. -
Antifungal/Exosome Inhibitor
Neticonazole hydrochloride is an imidazole derivative that acts as a potent antifungal agent through the inhibition of fungal sterol synthesis. In addition to its antifungal properties, it has shown promising anti-cancer effects, primarily through the modulation of exosome release and related pathways. This compound is suitable for research applications aimed at exploring antifungal therapies and investigating potential anti-cancer mechanisms. -
Fungal Inhibitor
Piroctone olamine is a pyridine derivative that acts as a potent fungal inhibitor by disrupting fungal cell membrane integrity. It exhibits fungicidal activity effective against a variety of dermatophytes and yeast, making it valuable for research in antifungal treatment and dermatological applications. Its mechanism of action supports investigations into fungal pathogenesis and the development of antifungal therapies. -
Antifungal Agent
Econazole is an orally active imidazole antifungal agent that primarily targets the cytochrome P-450 enzyme system. It demonstrates significant antifungal activity against various fungi and some Gram-positive bacteria, while lacking efficacy against Gram-negative bacteria. Additionally, econazole is known to inhibit prostaglandin synthesis and may induce hepatotoxicity, making it valuable in the study of antifungal resistance and the mechanisms of liver injury. -
Fungal Inhibitor
Dehydroacetic acid sodium is a pyrone derivative known for its fungicidal properties. It exhibits antibacterial and antifungal activity, making it valuable for applications in microbial control in various settings. Additionally, dehydroacetic acid demonstrates phytotoxic effects, indicating its potential use in agricultural research.
