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Elacridar (GF120918)

Catalog No.: A12324

P-gp & BCRP inhibitor

Elacridar (GF120918)

Elacridar (GF120918) Chemical Structure

CAS NO. 143664-11-3

Elacridaris a prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$65.00
25 mg
$150.00
50 mg
$210.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Leo Shen, .et al. A forward genetic screen identifies modifiers of rocaglate responsiveness, Sci Rep, 2021, Sep 16;11(1):18516 PMID: 34531456

Biological Activity

Elacridaris a prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport.
Targets
P-gp BCRP
In vitro (25°C) DMSO Warmed: 7 mg/mL (12.42 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.74 mL 88.71 mL 177.42 mL
0.5 mM 3.55 mL 17.74 mL 35.48 mL
1 mM 1.77 mL 8.87 mL 17.74 mL
5 mM 0.35 mL 1.77 mL 3.55 mL

*The above data is based on the productmolecular weight 563.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12324
Actions Inhibitor
CAS No. 143664-11-3
Formula C34H33N3O5
M. Wt 563.64
Purity >98%
SMILES COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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