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EPZ-6438 (Tazemetostat)


EZH2 inhibitor

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Catalog No. A12712

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
EPZ-6438 5mg A12712-5

Regular Price: $50.00

Special Price: $45.00

EPZ-6438 10mg A12712-10

Regular Price: $70.00

Special Price: $63.00

EPZ-6438 25mg A12712-25

Regular Price: $100.00

Special Price: $90.00

EPZ-6438 50mg A12712-50

Regular Price: $150.00

Special Price: $135.00

EPZ-6438 10mM * 1mL in DMSO A12712-10mM-D

Regular Price: $60.00

Special Price: $54.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.

EPZ-6438 (Tazemetostat)

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Publications citing Adooq Products
EPZ-6438 (Tazemetostat) Citations (2)
  • Wang Z, .et al. Targeting EZH 2 as a novel therapeutic strategy for sorafenib-resistant thyroid carcinoma, J Cell Mol Med, 2019, May 13 PMID: 31087496
  • Theresa Baker, .et al. Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors, Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609

Chemical Information

Catalog Num A12712
Actions Inhibitor
M. Wt 572.74
Formula C34H44N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1403254-99-8
Synonyms EPZ6438, EPZ 6438

Biological Activity

EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. It induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells.
EZH2 (Cell-free assay) EZH2 (Cell-free assay)
2.5 nM(Ki)2.5 nM(Ki)


Solubility (25°C)* In vitro DMSO 29 mg/mL (50.63 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.46 mL 87.3 mL 174.6mL
0.5 mM 3.49 mL 17.46 mL 34.92 mL
1 mM 1.75 mL 8.73 mL 17.46 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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