ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma.
ER-67880 is a potent microtubule inhibitor that disrupts microtubule dynamics with an IC50 of 9.5 μM. This compound demonstrates significant anti-proliferative effects against KB, Colon 38, and P338 cancer cell lines, with IC50 values of 0.55, 0.2, and 0.76 μg/mL, respectively. It causes G2/M phase cell cycle arrest and results in altered DNA replication patterns, alongside the down-regulation of G1 phase-related genes. ER-67880 is applicable in various cancer research studies, including those focused on nasopharyngeal carcinoma and murine adenocarcinoma.
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