ER Degrader 7 is a selective degrader of estrogen receptors ERα and ERβ, promoting their degradation to inhibit estrogen signaling. This compound demonstrates significant cytotoxicity in various breast cancer cell lines, with IC50 values of 0.06 µM in MCF-7, 2.56 µM in T47D, and varying values in other cell types. Additionally, ER Degrader 7 has been shown to impede tubulin polymerization, contributing to its effectiveness in inhibiting breast cancer tumor growth. This makes it a valuable tool for research into targeted therapies for hormone-driven malignancies.
ER Degrader 7 is a selective degrader of estrogen receptors ERα and ERβ, promoting their degradation to inhibit estrogen signaling. This compound demonstrates significant cytotoxicity in various breast cancer cell lines, with IC50 values of 0.06 µM in MCF-7, 2.56 µM in T47D, and varying values in other cell types. Additionally, ER Degrader 7 has been shown to impede tubulin polymerization, contributing to its effectiveness in inhibiting breast cancer tumor growth. This makes it a valuable tool for research into targeted therapies for hormone-driven malignancies.
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