Estromustine is the active metabolite of Estramustine phosphate, primarily targeting the mutant androgen receptor (m-AR). It demonstrates an EC50 of 2.6 μM in LNCaP prostate cancer cells and exhibits cytotoxicity with an IC50 of 9.73 μM. This compound is valuable for research focused on androgen receptor mutations and their role in prostate cancer therapeutics.
Estromustine is the active metabolite of Estramustine phosphate, primarily targeting the mutant androgen receptor (m-AR). It demonstrates an EC50 of 2.6 μM in LNCaP prostate cancer cells and exhibits cytotoxicity with an IC50 of 9.73 μM. This compound is valuable for research focused on androgen receptor mutations and their role in prostate cancer therapeutics.
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