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Biological Activity
ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule; activator of hepatic AMP-activated protein kinase (AMPK); also has potent inhibitory activity against hepatic ATP-citrate lyase(IC50=29 uM).
Targets
| AMPK | ||||
| In vitro | DMSO | 61 mg/mL (177.07 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.03 mL | 145.14 mL | 290.28 mL |
| 0.5 mM | 5.81 mL | 29.03 mL | 58.06 mL |
| 1 mM | 2.9 mL | 14.51 mL | 29.03 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.81 mL |
*The above data is based on the productmolecular weight 344.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15815 |
|---|---|
| Actions | Inhibitor, Activator |
| CAS No. | 738606-46-7 |
| Formula | C19H36O5 |
| M. Wt | 344.49 |
| Purity | >98% |
| Synonyms | ESP-55016, ETC1002, ETC 1002 |
| SMILES | CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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