Fenbendazole is an orally active benzimidazole compound that primarily targets tubulin, acting as a microtubule destabilizing agent. It exhibits a broad antiparasitic activity by disrupting microtubule equilibrium in helminths. Additionally, fenbendazole is known for its anti-proliferative effects, inducing apoptosis and causing cell-cycle arrest in various cancer models. Its antitumor properties have been demonstrated in mice xenografted with wild-type p53, making it a valuable reagent for exploring mechanisms of cancer therapy.
Fenbendazole is an orally active benzimidazole compound that primarily targets tubulin, acting as a microtubule destabilizing agent. It exhibits a broad antiparasitic activity by disrupting microtubule equilibrium in helminths. Additionally, fenbendazole is known for its anti-proliferative effects, inducing apoptosis and causing cell-cycle arrest in various cancer models. Its antitumor properties have been demonstrated in mice xenografted with wild-type p53, making it a valuable reagent for exploring mechanisms of cancer therapy.
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