Flurocitabine, a fluorinated analog of cytosine arabinoside, acts as an antineoplastic agent by undergoing partial hydrolysis in vivo to produce two active metabolites: arabinosyl-fluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU). This compound demonstrates significant antitumor activity and has shown promise in phase I clinical studies for acute leukemia and various solid tumors. Its unique mechanism of action makes Flurocitabine a valuable tool for cancer research and therapy development.
Flurocitabine, a fluorinated analog of cytosine arabinoside, acts as an antineoplastic agent by undergoing partial hydrolysis in vivo to produce two active metabolites: arabinosyl-fluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU). This compound demonstrates significant antitumor activity and has shown promise in phase I clinical studies for acute leukemia and various solid tumors. Its unique mechanism of action makes Flurocitabine a valuable tool for cancer research and therapy development.
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