Framycetin sulfate, an aminoglycoside antibiotic, primarily targets RNase P, functioning as a potent inhibitor of its cleavage activity with a Ki of 35 μM. It competes for divalent metal ion binding sites within RNase P RNA, effectively inhibiting the hammerhead ribozyme with a Ki of 13.5 μM. Additionally, as a 5″-azido neomycin B precursor, Framycetin sulfate binds to the Drosha site in miR-525, making it applicable in the study of hepatic encephalopathy and enteropathogenic E. coli infections.
Framycetin sulfate, an aminoglycoside antibiotic, primarily targets RNase P, functioning as a potent inhibitor of its cleavage activity with a Ki of 35 μM. It competes for divalent metal ion binding sites within RNase P RNA, effectively inhibiting the hammerhead ribozyme with a Ki of 13.5 μM. Additionally, as a 5″-azido neomycin B precursor, Framycetin sulfate binds to the Drosha site in miR-525, making it applicable in the study of hepatic encephalopathy and enteropathogenic E. coli infections.
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