FzM1.8

Catalog No.: A18760

FZD4 agonist

FzM1.8

FzM1.8 Chemical Structure

CAS NO. 2204290-85-5

FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.03 mL 155.13 mL 310.25 mL
0.5 mM 6.21 mL 31.03 mL 62.05 mL
1 mM 3.1 mL 15.51 mL 31.03 mL
5 mM 0.62 mL 3.1 mL 6.21 mL

*The above data is based on the productmolecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18760
Actions Agonist
M. Wt 322.32
Formula C18H14N2O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2204290-85-5
Synonyms FzM1.8; FzM-1.8; FzM 1.8
SMILES O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1

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