G36 is a cell-permeable antagonist of the G protein-coupled estrogen receptor GPER (GPR30). It selectively inhibits estrogen-induced activation of the PI3K pathway and effective calcium mobilization, with an IC50 value of 112 nM. G36 holds significant promise for research applications in cancer biology, particularly in studies focusing on estrogen signaling pathways and their implications in tumorigenesis.
G36 is a cell-permeable antagonist of the G protein-coupled estrogen receptor GPER (GPR30). It selectively inhibits estrogen-induced activation of the PI3K pathway and effective calcium mobilization, with an IC50 value of 112 nM. G36 holds significant promise for research applications in cancer biology, particularly in studies focusing on estrogen signaling pathways and their implications in tumorigenesis.
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