Galantide serves as a non-specific antagonist of galanin receptors, comprised of peptides derived from galanin and substance P. It effectively recognizes two distinct classes of galanin binding sites in the rat hypothalamus, with dissociation constants (KD) of less than 0.1 nM and approximately 6 nM. Galantide demonstrates dose-dependent antagonism (IC50 = 1.0 nM) of galanin-mediated inhibition on glucose-induced insulin secretion in mouse pancreatic islets. Additionally, it binds to a singular population of substance P receptors with a KD of around 40 nM, demonstrating its potential for investigating galanin signaling pathways and their physiological effects.
Galantide serves as a non-specific antagonist of galanin receptors, comprised of peptides derived from galanin and substance P. It effectively recognizes two distinct classes of galanin binding sites in the rat hypothalamus, with dissociation constants (KD) of less than 0.1 nM and approximately 6 nM. Galantide demonstrates dose-dependent antagonism (IC50 = 1.0 nM) of galanin-mediated inhibition on glucose-induced insulin secretion in mouse pancreatic islets. Additionally, it binds to a singular population of substance P receptors with a KD of around 40 nM, demonstrating its potential for investigating galanin signaling pathways and their physiological effects.
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