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GLI antagonist

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Catalog No. A13252

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
GANT61 10mg A13252-10

Regular Price: $75.00

Special Price: $67.50

GANT61 25mg A13252-25

Regular Price: $150.00

Special Price: $135.00

GANT61 50mg A13252-50

Regular Price: $280.00

Special Price: $252.00

GANT61 100mg A13252-100

Regular Price: $480.00

Special Price: $432.00

GANT61 10mM * 1mL in DMSO A13252-10mM-D

Regular Price: $55.00

Special Price: $49.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.


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Publications citing Adooq Products
GANT61 Citations (1)
  • Hui Liang,et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 28098170

Chemical Information

Catalog Num A13252
Actions Antagonist
M. Wt 429.61
Formula C27H35N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 500579-04-4
Synonyms NSC136476, NSC-136476, GANT 61, GANT-61
Chemical Name 2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2?H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimeth?ylbenzenamine

Biological Activity

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
GLI1 (HEK293T cells expressing GLI1)
5 μM


Solubility (25°C) * In vitro DMSO 12 mg/mL (27.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.28 mL 116.38 mL 232.77mL
0.5 mM 4.66 mL 23.28 mL 46.55 mL
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL

*The above data is based on the productmolecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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