GANT61

Catalog No.: A13252

GLI antagonist

GANT61

GANT61 Chemical Structure

CAS NO. 500579-04-4

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.

Availability: In stock

Package Price Qty
10 mg
$75.00
25 mg
$150.00
50 mg
$280.00
100 mg
$480.00
10mM * 1mL in DMSO
$55.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170

Biological Activity

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
Targets
GLI1 (HEK293T cells expressing GLI1)
5 μM
In vitro (25°C) DMSO 12 mg/mL (27.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO/95% Corn oil 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.28 mL 116.38 mL 232.77 mL
0.5 mM 4.66 mL 23.28 mL 46.55 mL
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL

*The above data is based on the productmolecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13252
Actions Antagonist
M. Wt 429.61
Formula C27H35N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 500579-04-4
Synonyms NSC136476, NSC-136476, GANT 61, GANT-61
SMILES CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C

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