Total item
Cart Subtotal
$0.00 - Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170
Biological Activity
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
Targets
| GLI1 (HEK293T cells expressing GLI1) | ||||
| 5 μM |
| In vitro (25°C) | DMSO | 12 mg/mL (27.93 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 5% DMSO/95% Corn oil | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.28 mL | 116.38 mL | 232.77 mL |
| 0.5 mM | 4.66 mL | 23.28 mL | 46.55 mL |
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13252 |
|---|---|
| Actions | Antagonist |
| M. Wt | 429.61 |
| Formula | C27H35N5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 500579-04-4 |
| Synonyms | NSC136476, NSC-136476, GANT 61, GANT-61 |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy GANT61 | GANT61 Supplier | purchase | cost | manufacturer | order | distributor | buy 500579-04-4| 500579-04-4 Supplier | purchase 500579-04-4 | 500579-04-4 cost | 500579-04-4 manufacturer | order 500579-04-4 | 500579-04-4 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.