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$0.00 - Cheng Zhou, .et al. GLI1 reduces drug sensitivity by regulating cell cycle through PI3K/AKT/GSK3/CDK pathway in acute myeloid leukemia, Cell Death Dis, 2021, Mar 3;12(3):231 PMID: 33658491
- Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170
Biological Activity
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
Targets
| GLI1 (HEK293T cells expressing GLI1) | ||||
| 5 μM |
| In vitro | DMSO | Insoluble | |
| Water | Insoluble | ||
| Ethanol | 11 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.28 mL | 116.38 mL | 232.77 mL |
| 0.5 mM | 4.66 mL | 23.28 mL | 46.55 mL |
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13252 |
|---|---|
| Actions | Antagonist |
| CAS No. | 500579-04-4 |
| Formula | C27H35N5 |
| M. Wt | 429.61 |
| Purity | >98% |
| Synonyms | NSC136476, NSC-136476, GANT 61, GANT-61 |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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