Gemcitabine HCl (Gemzar)

Catalog No.: A10423

DNA/RNA Synthesis inhibitor

Gemcitabine HCl (Gemzar)

Gemcitabine HCl (Gemzar) Chemical Structure

CAS NO. 122111-03-9

Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.

Availability: In stock

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25 mg

Regular Price: $30.00

Special Price $24.00

50 mg

Regular Price: $40.00

Special Price $32.00

100 mg

Regular Price: $50.00

Special Price $40.00

200 mg

Regular Price: $60.00

Special Price $48.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269

Biological Activity

Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
Targets
DNA synthesis (Capan2 cells) DNA synthesis (BxPC3 cells) DNA synthesis (MIAPaCa2 cells) DNA synthesis (PANC1 cells)
12 nM18 nM40 nM50 nM
In vitro (25°C) DMSO Insoluble
Water 18 mg/mL (60.06 mM)
Ethanol Insoluble
In vivo Saline 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.37 mL 166.83 mL 333.67 mL
0.5 mM 6.67 mL 33.37 mL 66.73 mL
1 mM 3.34 mL 16.68 mL 33.37 mL
5 mM 0.67 mL 3.34 mL 6.67 mL

*The above data is based on the productmolecular weight 299.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10423
Actions Inhibitor
CAS No. 122111-03-9
Formula C9H11F2N3O4.HCI
M. Wt 299.7
Purity >98%
SMILES C1=CN(C(=O)N=C1N)[[email protected]]2C([[email protected]@H]([[email protected]](O2)CO)O)(F)F.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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