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- G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269
Biological Activity
Gemcitabine (Gemzar) is a newer chemotherapy drug acting by replacing one of the building blocks of nucleic acids during DNA replication in cancer cells, preventing tumor growth.
Targets
| DNA synthesis (Capan2 cells) | DNA synthesis (BxPC3 cells) | DNA synthesis (MIAPaCa2 cells) | DNA synthesis (PANC1 cells) | |
| 12 nM | 18 nM | 40 nM | 50 nM |
| In vitro (25°C) | DMSO | Insoluble | |
| Water | 18 mg/mL (60.06 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | Saline | 18 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.37 mL | 166.83 mL | 333.67 mL |
| 0.5 mM | 6.67 mL | 33.37 mL | 66.73 mL |
| 1 mM | 3.34 mL | 16.68 mL | 33.37 mL |
| 5 mM | 0.67 mL | 3.34 mL | 6.67 mL |
*The above data is based on the productmolecular weight 299.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10423 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 122111-03-9 |
| Formula | C9H11F2N3O4.HCI |
| M. Wt | 299.7 |
| Purity | >98% |
| SMILES | C1=CN(C(=O)N=C1N)[[email protected]]2C([[email protected]@H]([[email protected]](O2)CO)O)(F)F.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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