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Biological Activity
Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.84 mL | 109.18 mL | 218.36 mL |
| 0.5 mM | 4.37 mL | 21.84 mL | 43.67 mL |
| 1 mM | 2.18 mL | 10.92 mL | 21.84 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21487 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 199657-29-9 |
| Formula | C24H28ClN3O4 |
| M. Wt | 457.95 |
| Purity | >98% |
| Synonyms | ITF-2357 hydrochloride, ITF2357, ITF 2357 |
| SMILES | O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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