Go 6976

Name: Go 6976
Brand: Adooq Bioscience
SKU: A12419
Rating: 100 (268 reviews)

Catalog No.: A12419

PKC inhibitor

Go 6976 Chemical Structure

CAS NO. 136194-77-9

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Availability: Out of stock

Package	Price
5 mg	$140.00
10 mg	$250.00
25 mg	$350.00
50 mg	$650.00
10mM * 1mL in DMSO	$180.00
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Biological Activity

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Targets

JAK2	FLT3	PKCα	PKCβ1	PKC (Rat brain)
N/A		2.3 nM	6.2 nM	7.9 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 18 mg/mL (47.69 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC Na+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.42 mL	132.12 mL	264.25 mL
0.5 mM	5.28 mL	26.42 mL	52.85 mL
1 mM	2.64 mL	13.21 mL	26.42 mL
5 mM	0.53 mL	2.64 mL	5.28 mL

*The above data is based on the productmolecular weight 378.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12419
Actions	Inhibitor
CAS No.	136194-77-9
Formula	C24H18N4O
M. Wt	378.43
Purity	>98%
Synonyms	Go6976, Go-6976
SMILES	CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.