Go 6976

Catalog No.: A12419

PKC inhibitor

Go 6976

Go 6976 Chemical Structure

CAS NO. 136194-77-9

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Availability: Out of stock

Package Price
5 mg
$140.00
10 mg
$250.00
25 mg
$350.00
50 mg
$650.00
10mM * 1mL in DMSO
$180.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
Targets
JAK2 FLT3 PKCα PKCβ1 PKC (Rat brain)
N/A2.3 nM6.2 nM7.9 nM
In vitro DMSO 18 mg/mL heating (47.69 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.42 mL 132.12 mL 264.25 mL
0.5 mM 5.28 mL 26.42 mL 52.85 mL
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL

*The above data is based on the productmolecular weight 378.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12419
Actions Inhibitor
M. Wt 378.43
Formula C24H18N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 136194-77-9
Synonyms Go6976, Go-6976
SMILES CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

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