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Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
Targets
| Akt3 | Akt1 | Akt2 | ||
| 38 nM | 180 nM | 328 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.3 mL | 116.48 mL | 232.96 mL |
| 0.5 mM | 4.66 mL | 23.3 mL | 46.59 mL |
| 1 mM | 2.33 mL | 11.65 mL | 23.3 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15809 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 429.25 |
| Formula | C18H16Cl2F2N4O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1047634-65-0 |
| Synonyms | GSK2141795, GSK2141795, Uprosertib, GSK 795 |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl |
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