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Biological Activity
Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
Targets
| Akt3 | Akt1 | Akt2 | ||
| 38 nM | 180 nM | 328 nM |
| In vitro | DMSO | 80 mg/mL (186.36 mM) | |
| Water | Insoluble | ||
| Ethanol | 80 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.3 mL | 116.48 mL | 232.96 mL |
| 0.5 mM | 4.66 mL | 23.3 mL | 46.59 mL |
| 1 mM | 2.33 mL | 11.65 mL | 23.3 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15809 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1047634-65-0 |
| Formula | C18H16Cl2F2N4O2 |
| M. Wt | 429.25 |
| Purity | >98% |
| Synonyms | GSK2141795, GSK2141795, Uprosertib, GSK 795 |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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