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GSK2141795 (Uprosertib, GSK795)

GSK2141795 (Uprosertib, GSK795)

Name: GSK2141795 (Uprosertib, GSK795)
Brand: Adooq Bioscience
SKU: A15809
Rating: 100 (268 reviews)

Catalog No.: A15809

Akt inhibitor

GSK2141795 (Uprosertib, GSK795) Chemical Structure

CAS NO. 1047634-65-0

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

Availability: In stock

Package	Price	Qty
5 mg	$81.00
10 mg	$138.00
25 mg	$243.00
Custom Size	Get quote

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Biological Activity

Targets

Akt3	Akt1	Akt2
38 nM	180 nM	328 nM

Solubility *

In vitro	DMSO	80 mg/mL (186.36 mM)
	Water	Insoluble
	Ethanol	80 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.3 mL	116.48 mL	232.96 mL
0.5 mM	4.66 mL	23.3 mL	46.59 mL
1 mM	2.33 mL	11.65 mL	23.3 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

*The above data is based on the productmolecular weight 429.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A15809
Actions	Inhibitor
CAS No.	1047634-65-0
Formula	C18H16Cl2F2N4O2
M. Wt	429.25
Solubility	DMSO
Purity	>98%
Synonyms	GSK2141795, GSK2141795, Uprosertib, GSK 795
SMILES	CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.