GSK2141795 (Uprosertib, GSK795)

Catalog No.: A15809

Akt inhibitor

GSK2141795 (Uprosertib, GSK795)

GSK2141795 (Uprosertib, GSK795) Chemical Structure

CAS NO. 1047634-65-0

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

Availability: In stock

Package Price Qty
5 mg
$81.00
10 mg
$138.00
25 mg
$243.00
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Biological Activity

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
Targets
Akt3 Akt1 Akt2
38 nM180 nM328 nM
In vitro DMSO 80 mg/mL (186.36 mM)
Water Insoluble
Ethanol 80 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.3 mL 116.48 mL 232.96 mL
0.5 mM 4.66 mL 23.3 mL 46.59 mL
1 mM 2.33 mL 11.65 mL 23.3 mL
5 mM 0.47 mL 2.33 mL 4.66 mL

*The above data is based on the productmolecular weight 429.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15809
Actions Inhibitor
CAS No. 1047634-65-0
Formula C18H16Cl2F2N4O2
M. Wt 429.25
Purity >98%
Synonyms GSK2141795, GSK2141795, Uprosertib, GSK 795
SMILES CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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