GW284543 hydrochloride

Catalog No.: A65814
MEK5 Inhibitor
GW284543 hydrochloride is a selective inhibitor of MEK5, a key regulator in the MAPK signaling pathway. This compound effectively reduces phosphorylated ERK5 (pERK5) levels while decreasing the endogenous MYC protein. It is valuable for research applications investigating cellular signaling pathways, tumor biology, and potential therapeutic targets in various cancers.
Grouped product items
Size Price Stock Qty
1mg
$25.00
In stock
5mg
$50.00
In stock
10mg
$85.00
In stock
25mg
$170.00
In stock
50mg
$280.00
In stock
100mg
$375.00
In stock
200mg
$465.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionGW284543 hydrochloride is a selective inhibitor of MEK5, a key regulator in the MAPK signaling pathway. This compound effectively reduces phosphorylated ERK5 (pERK5) levels while decreasing the endogenous MYC protein. It is valuable for research applications investigating cellular signaling pathways, tumor biology, and potential therapeutic targets in various cancers.
Product Information
Catalog NumA65814
FormulaC23H21ClN2O3
Molecular Weight408.88
CAS Number179246-08-3
SMILESCOC1=CC2=C(NC3=CC(OC4=CC=CC=C4)=CC=C3)C=CN=C2C=C1OC.Cl
SynonymsUNC10225170 hydrochloride
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