Halofantrine hydrochloride is an antimalarial agent that primarily targets human ERG channels, inhibiting the delayed rectifier potassium current. This compound demonstrates significant antimalarial activity against Plasmodium strains in both in vitro and animal models, while also exhibiting antifungal properties by inhibiting the Cap1-dependent oxidative stress response in Candida albicans. Its effectiveness extends to enhancing the antifungal activity of agents inducing oxidative damage and is particularly relevant for research on invasive candidiasis, falciparum malaria, and vivax malaria.
Halofantrine hydrochloride is an antimalarial agent that primarily targets human ERG channels, inhibiting the delayed rectifier potassium current. This compound demonstrates significant antimalarial activity against Plasmodium strains in both in vitro and animal models, while also exhibiting antifungal properties by inhibiting the Cap1-dependent oxidative stress response in Candida albicans. Its effectiveness extends to enhancing the antifungal activity of agents inducing oxidative damage and is particularly relevant for research on invasive candidiasis, falciparum malaria, and vivax malaria.
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