HDAC1-IN-10 is a selective inhibitor targeting HDAC1 and HDAC2, exhibiting potent activity with IC50 values of 6 nM and 190 nM, respectively, while showing minimal activity against HDAC3-8 (IC50 > 50 μM). This compound demonstrates efficacy in inhibiting tumor growth in HCT-116 colon cancer xenograft models, making it a valuable tool for studying the role of histone deacetylases in colon cancer research. It serves as a potential lead for therapeutic strategies aimed at HDAC-related malignancies.
HDAC1-IN-10 is a selective inhibitor targeting HDAC1 and HDAC2, exhibiting potent activity with IC50 values of 6 nM and 190 nM, respectively, while showing minimal activity against HDAC3-8 (IC50 > 50 μM). This compound demonstrates efficacy in inhibiting tumor growth in HCT-116 colon cancer xenograft models, making it a valuable tool for studying the role of histone deacetylases in colon cancer research. It serves as a potential lead for therapeutic strategies aimed at HDAC-related malignancies.
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