HDAC6-IN-13 is a potent and highly selective inhibitor of HDAC6, exhibiting an IC50 of 0.019 μM. While selectively targeting HDAC6, this compound also affects HDAC1, HDAC2, and HDAC3, with IC50 values of 1.53, 2.06, and 1.03 μM, respectively. Notably, HDAC6-IN-13 demonstrates significant blood-brain barrier permeability and possesses anti-inflammatory properties, making it a valuable tool for research in neuroinflammation and associated neurological disorders.
HDAC6-IN-13 is a potent and highly selective inhibitor of HDAC6, exhibiting an IC50 of 0.019 μM. While selectively targeting HDAC6, this compound also affects HDAC1, HDAC2, and HDAC3, with IC50 values of 1.53, 2.06, and 1.03 μM, respectively. Notably, HDAC6-IN-13 demonstrates significant blood-brain barrier permeability and possesses anti-inflammatory properties, making it a valuable tool for research in neuroinflammation and associated neurological disorders.
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