HDAC6-IN-34 is a selective inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 18 nM, exhibiting oral bioactivity. This compound significantly increases the acetylation of tubulin while leaving histone acetylation unaffected in cutaneous T-cell lymphoma cells. In addition, HDAC6-IN-34 effectively inhibits TNF-α secretion in lipopolysaccharide-stimulated macrophages. Notably, it demonstrates potent anti-arthritic efficacy in rat models, making it a valuable tool for researching inflammatory diseases and cancer therapies.
HDAC6-IN-34 is a selective inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 18 nM, exhibiting oral bioactivity. This compound significantly increases the acetylation of tubulin while leaving histone acetylation unaffected in cutaneous T-cell lymphoma cells. In addition, HDAC6-IN-34 effectively inhibits TNF-α secretion in lipopolysaccharide-stimulated macrophages. Notably, it demonstrates potent anti-arthritic efficacy in rat models, making it a valuable tool for researching inflammatory diseases and cancer therapies.
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