HDAC6-IN-53 is a potent inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. This compound effectively suppresses collagen expression induced by TGF-β1, demonstrating therapeutic potential in the treatment of idiopathic pulmonary fibrosis (IPF). Additionally, HDAC6-IN-53 has shown efficacy in a mouse model of pulmonary fibrosis induced by Bleomycin. It is a valuable reagent for studying the molecular mechanisms underlying idiopathic pulmonary fibrosis and related pulmonary diseases.
HDAC6-IN-53 is a potent inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. This compound effectively suppresses collagen expression induced by TGF-β1, demonstrating therapeutic potential in the treatment of idiopathic pulmonary fibrosis (IPF). Additionally, HDAC6-IN-53 has shown efficacy in a mouse model of pulmonary fibrosis induced by Bleomycin. It is a valuable reagent for studying the molecular mechanisms underlying idiopathic pulmonary fibrosis and related pulmonary diseases.
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