HIV-1 inhibitor-51 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1, demonstrating potent antiviral activity against both wild-type and mutant strains. It exhibits a high binding affinity with a KD of 2.50 μM and shows significant inhibitory potency with an IC50 of 0.03 μM against wild-type HIV-1 reverse transcriptase. Additionally, HIV-1 inhibitor-51 has effective EC50 values ranging from 2.22 to 53.3 nM against a range of clinically relevant mutant strains, making it a valuable tool for research in HIV-1 drug resistance and antiviral drug development.
HIV-1 inhibitor-51 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1, demonstrating potent antiviral activity against both wild-type and mutant strains. It exhibits a high binding affinity with a KD of 2.50 μM and shows significant inhibitory potency with an IC50 of 0.03 μM against wild-type HIV-1 reverse transcriptase. Additionally, HIV-1 inhibitor-51 has effective EC50 values ranging from 2.22 to 53.3 nM against a range of clinically relevant mutant strains, making it a valuable tool for research in HIV-1 drug resistance and antiviral drug development.
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