IACS-4619 is a highly selective inhibitor of the MTH1 enzyme (MutT homolog 1) with an IC50 of 0.2 nM. This 2-aminopyrimidine compound effectively blocks the hydrolysis of oxidized purine nucleotides, such as 8-oxo-dGTP, preventing the incorporation of these nucleotides into DNA. Notably, IACS-4619 demonstrates significant inhibition of endogenous MTH1 activity in MTH1-overexpressing U2OS cells without exhibiting antiproliferative or cytotoxic effects on various human cancer and normal cell lines. This reagent is applicable in oncology research targeting the MTH1 pathway.
IACS-4619 is a highly selective inhibitor of the MTH1 enzyme (MutT homolog 1) with an IC50 of 0.2 nM. This 2-aminopyrimidine compound effectively blocks the hydrolysis of oxidized purine nucleotides, such as 8-oxo-dGTP, preventing the incorporation of these nucleotides into DNA. Notably, IACS-4619 demonstrates significant inhibition of endogenous MTH1 activity in MTH1-overexpressing U2OS cells without exhibiting antiproliferative or cytotoxic effects on various human cancer and normal cell lines. This reagent is applicable in oncology research targeting the MTH1 pathway.
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