IK-595 is a selective inhibitor of MEK1 and MEK2, exhibiting a high binding affinity of 7.39 nM. It effectively blocks EGF-induced phosphorylation of ERK1/2 in AsPC-1 cells, with an IC50 of 0.1 nM. Notably, IK-595 demonstrates oral bioavailability and the ability to penetrate the blood-brain barrier, making it a valuable tool for investigating Ras/MAPK pathway-altered cancers.
IK-595 is a selective inhibitor of MEK1 and MEK2, exhibiting a high binding affinity of 7.39 nM. It effectively blocks EGF-induced phosphorylation of ERK1/2 in AsPC-1 cells, with an IC50 of 0.1 nM. Notably, IK-595 demonstrates oral bioavailability and the ability to penetrate the blood-brain barrier, making it a valuable tool for investigating Ras/MAPK pathway-altered cancers.
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