Ilicicolin H is a selective inhibitor of phosphoglycerate kinase 1 (PGK1) and mitochondrial cytochrome bc1 reductase, with an IC50 of 9.02 μM and 2-3 ng/mL, respectively. It effectively inhibits cell proliferation and induces apoptosis in cancer cells, particularly hepatocellular carcinoma (HCC), by reducing lactate production and glucose uptake. Additionally, Ilicicolin H displays broad antifungal activity against pathogens such as Candida albicans, Cryptococcus species, and Aspergillus fumigatus. This compound is suitable for research applications in oncology and infectious diseases.
Ilicicolin H is a selective inhibitor of phosphoglycerate kinase 1 (PGK1) and mitochondrial cytochrome bc1 reductase, with an IC50 of 9.02 μM and 2-3 ng/mL, respectively. It effectively inhibits cell proliferation and induces apoptosis in cancer cells, particularly hepatocellular carcinoma (HCC), by reducing lactate production and glucose uptake. Additionally, Ilicicolin H displays broad antifungal activity against pathogens such as Candida albicans, Cryptococcus species, and Aspergillus fumigatus. This compound is suitable for research applications in oncology and infectious diseases.
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