Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Ropinirole-d4 hydrochloride is a deuterium-labeled derivative of Ropinirole hydrochloride, functioning primarily as a selective D2/D3 receptor agonist. It exhibits a Kiof of 29 nM for the D2 receptor and demonstrates pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively. With its specific action and lack of affinity for D1 receptors, Ropinirole-d4 is particularly valuable in investigations related to Parkinson's disease and receptor pharmacology. -
Stable Isotope
Didesmethyl cariprazine-d8 is a deuterium-labeled derivative of didesmethyl cariprazine, a metabolite of the antipsychotic drug Cariprazine. This compound acts as a partial agonist at dopamine D2 and D3 receptors, a full agonist at the serotonin 5-HT1A receptor, and an antagonist at the 5-HT2B receptor. Its activity has been shown to dose-dependently inhibit the spontaneous firing of rat midbrain dopaminergic neurons, making it valuable for research in psychiatric disorders and neuropharmacology. -
Stable Isotope
Molindone-d8 is a deuterated form of the antipsychotic agent molindone, primarily used as a stable isotope in scientific research. Its primary mechanism involves dopamine receptor antagonism, reducing the effects of dopamine and helping to mitigate symptoms of schizophrenia. This labeled compound is particularly valuable in pharmacokinetic studies and metabolic research, allowing for precise tracking and analysis of drug behavior in biological systems. -
Stable Isotope
Ropinirole-d14 hydrochloride is a deuterated analog of Ropinirole hydrochloride, functioning primarily as a D3/D2 receptor agonist. It exhibits a Ki value of 29 nM for the D2 receptor and pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively. This compound is instrumental in studying Parkinson's disease due to its targeted pharmacological activity and lack of affinity for D1 receptors, making it a valuable tool in neuropharmacological research. -
Stable Isotope
Ropinirole-d3 is a deuterated analog of Ropinirole, primarily targeting D3 and D2 dopamine receptors. As a potent agonist, Ropinirole exhibits a Ki value of 29 nM for the D2 receptor, alongside pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively. This stable isotope is useful in pharmacokinetic studies and can provide insights into the mechanism of action related to dopaminergic therapies, particularly in the context of Parkinson's disease research. -
Stable Isotope
Domperidone-d6 is a deuterium-labeled derivative of Domperidone, a selective antagonist of dopamine D2 receptors. It exerts antiemetic and prokinetic effects by modulating the chemoreceptor trigger zone and enhancing gastrointestinal motility. This stable isotope serves as a valuable tool for research applications, including pharmacokinetic studies and metabolic pathway investigations. -
Stable Isotope
Metopimazine-d6 is a deuterium-labeled derivative of Metopimazine, a phenothiazine compound that functions primarily as a selective antagonist of dopamine D2 receptors. It is characterized by its inability to penetrate the blood-brain barrier, making it effective in inhibiting dopamine activity in peripheral regions and the chemoreceptor trigger zone, thus reducing nausea and vomiting. Metopimazine is commonly utilized in the management of chemotherapy-induced nausea and vomiting, with minimal central nervous system effects owing to its limited brain access. This stable isotope compound is valuable for research applications involving pharmacokinetics and metabolic studies. -
Stable Isotope
Haloperidol-d4 N-Oxide is a deuterium-labeled derivative of Haloperidol, functioning primarily as a stable isotope. This compound serves as a potent antagonist of the dopamine D2 receptor and is extensively utilized in antipsychotic research. Its isotopic labeling facilitates advanced pharmacokinetic studies, enabling researchers to investigate the metabolism and dynamics of Haloperidol in biological systems. -
Stable Isotope
Promazine-d6 hydrochloride is a deuterium-labeled derivative of the antipsychotic agent promazine, which targets the dopamine D2 receptor. This stable isotope compound is utilized in pharmacokinetic studies and isotopic labeling applications. By inhibiting dopaminergic neurotransmission, it plays a critical role in understanding the mechanisms underlying neuropsychiatric disorders and the metabolic pathways of antipsychotic drugs. -
Stable Isotope
Ropinirole-d3 hydrochloride is a deuterium-labeled derivative of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors, with a Ki value of 29 nM for the D2 receptor. It exhibits pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is primarily utilized in research related to dopamine receptor signaling and has potential implications for therapies targeting Parkinson's disease. -
Stable Isotope
Raclopride-d5 hydrochloride is a deuterium-labeled derivative of Raclopride, a selective antagonist for dopamine D2 and D3 receptors. It exhibits high affinity, with dissociation constants (Kis) of 1.8 nM for D2 and 3.5 nM for D3 receptors, while demonstrating minimal interaction with D1 and D4 receptors (Kis of 18000 nM and 2400 nM, respectively). This compound is valuable in neuropharmacology research for studying dopamine signaling pathways and receptor mechanisms in various models. -
Stable Isotope
7α,25-Dihydroxycholesterol-d6 is a deuterated form of 7α,25-Dihydroxycholesterol, functioning as a selective agonist and endogenous ligand for the orphan G protein-coupled receptor EBI2 (GPR183). This stable isotope is crucial for studies involving lipid metabolism and immune response, particularly in relation to the modulation of B cell trafficking. Researchers utilize 7α,25-Dihydroxycholesterol-d6 in various biochemical assays to elucidate signaling pathways mediated by EBI2. -
Stable Isotope
Bosentan-d4 is a deuterium-labeled form of Bosentan, which acts as a competitive dual antagonist of endothelin-1 (ET) at both the ETA and ETB receptors, exhibiting Ki values of 4.7 nM and 95 nM in human smooth muscle cells, respectively. This reagent is primarily utilized in pharmacokinetic and metabolic studies, providing insights into the biological processes modulated by endothelin signaling. Its stable isotope labeling enhances the accuracy of quantification in analytical applications and research focused on cardiovascular disease mechanisms. -
Stable Isotope
(Rac)-Ambrisentan-d3 is a deuterated form of (Rac)-Ambrisentan, a selective endothelin receptor antagonist. This stable isotope is utilized in pharmacokinetic studies and metabolic research, allowing for precise tracking of drug metabolism and distribution in biological systems. Its application is essential for understanding the pharmacological properties and efficacy of endothelin receptor-targeted therapies. -
Stable Isotope
L-Methionine-13C,d3 is a stable isotope-labeled form of the essential amino acid L-Methionine, featuring both carbon-13 and deuterium labeling. L-Methionine plays a crucial role in human development and functions as a hepatoprotectant, supporting liver health. This reagent is valuable for metabolic studies, isotopic tracing experiments, and research into amino acid metabolism. -
Stable Isotope
Hippuric acid-d5 is a deuterated form of hippuric acid, a metabolite resulting from the conjugation of benzoic acid and glycine. This stable isotope serves as a valuable tool for tracking metabolic pathways and understanding the excretion of aromatic compounds from dietary sources. Its applications include pharmacokinetic studies and metabolic profiling in various biochemical research settings. -
Stable Isotope
Estradiol-d4 is a deuterated form of the steroid hormone estradiol, functioning as a stable isotope. It plays a critical role in regulating fertility and the development of secondary sexual characteristics in females. Estradiol-d4 is utilized in research to study estrogen signaling, particularly its influence on interleukin-6 (IL-6) expression via the estrogen receptor β (ERβ) pathway, enabling precise quantification and analysis in various biological studies. -
Stable Isotope
L-Leucine-13C6,15N is a stable isotope-labeled form of L-Leucine, incorporating both carbon-13 and nitrogen-15 isotopes. This essential branched-chain amino acid (BCAA) plays a crucial role in activating the mTOR signaling pathway, which is important for regulating cell growth and metabolism. L-Leucine-13C6,15N is widely utilized in metabolic studies and tracer experiments to investigate protein synthesis and amino acid metabolism in various biological systems. -
Stable Isotope
L-Aspartic acid-d3 is a deuterium-labeled analog of L-Aspartic acid, known for its ability to penetrate the blood-brain barrier. This amino acid plays a significant role in various metabolic pathways and is utilized in synthesizing prodrugs aimed at colon and cecal tissues. Additionally, L-Aspartic acid-d3 is valuable in research on inflammatory conditions, enabling precise tracking and assessment of metabolic processes. -
Stable Isotope
L-Cysteine-d3 is a deuterium-labeled derivative of L-Cysteine, a conditionally essential amino acid. This compound serves as a precursor for key biological molecules, including hydrogen sulfide (H2S), glutathione, and taurine. L-Cysteine-d3 is valuable for research applications investigating metabolic pathways, appetite regulation, and the synthesis of reactive sulfur species. Its stable isotope labeling facilitates the study of L-Cysteine's roles in various physiological processes. -
Stable Isotope
L-Aspartic acid-13C4 is a stable isotope-labeled variant of L-Aspartic acid, an amino acid capable of crossing the blood-brain barrier. This compound is utilized in research focusing on prodrug formulation to effectively target colon and cecal tissues. Additionally, L-Aspartic acid-13C4 serves as a valuable tool in studying various inflammatory conditions, enhancing the understanding of metabolic and pathological processes. -
Stable Isotope
L-Proline-d3 is a deuterium-labeled derivative of L-Proline, an essential amino acid integral to protein synthesis in living organisms. This stable isotope serves as a valuable tool in biochemical research, particularly in studies involving metabolic pathways, protein folding, and structure-function relationships of proteins. Its unique labeling facilitates advanced analytical techniques, including NMR and mass spectrometry, enabling precise tracking of metabolic processes and biomolecular interactions. -
Stable Isotope
Benzyl alcohol-d1 is a deuterium-labeled derivative of benzyl alcohol, serving as a stable isotope. It is primarily utilized in research applications such as mass spectrometry and metabolic studies, enabling the tracing of biological pathways and the quantitation of metabolites. Its distinct isotopic signature allows for enhanced specificity in chemical analysis and improved detection limits in various experimental setups. -
Stable Isotope
Fumaric acid-13C4 is a stable isotope-labeled form of fumaric acid, primarily utilized in metabolic studies and tracer experiments. Fumaric acid is recognized as an oncometabolite, implicated in fumarase deficiency and various cancer-related processes. The incorporation of the 13C label facilitates advanced research applications, including metabolic flux analysis and the investigation of biochemical pathways associated with cancer metabolism. -
Stable Isotope
3-Indoleacetic acid-d7 is a deuterium-labeled derivative of 3-Indoleacetic acid, a pivotal auxin and plant growth hormone. This stable isotope is employed in various research applications, particularly in studies investigating the mechanisms of plant growth and development. By incorporating 3-Indoleacetic acid-d7 into cell culture mediums, researchers can effectively explore the dynamics of cell elongation and division in plant systems. -
Stable Isotope
Glycolic acid-d2 is a deuterium-labeled variant of glycolic acid, functioning as a stable isotope. It acts as a selective inhibitor of tyrosinase, effectively suppressing melanin production, which can lead to skin lightening effects. This reagent is valuable for studies in skin biology, cosmetic research, and investigations into pigmentation processes. -
Stable Isotope
Glycerol-13C3 is a stable isotope-labeled form of glycerol, featuring three carbon-13 atoms. It serves as a valuable tool in sample preparation and is commonly employed in polyacrylamide gel electrophoresis to enhance the sensitivity of detection methods. The incorporation of Glycerol-13C3 allows for precise quantification and tracking of metabolic pathways in various biological studies. -
Stable Isotope
Hypoxanthine-d4 is a deuterium-labeled derivative of hypoxanthine, which serves as a stable isotope. It exhibits potential as a free radical generator and can be utilized as an indicator of hypoxic conditions. This compound is suitable for research applications focused on metabolism, hypoxia-related studies, and oxidative stress investigations, providing a valuable tool for analyzing purine metabolism and its implications in various biological processes. -
Stable Isotope
Cholesterol-13C2 is a stable isotope-labeled form of cholesterol, a critical sterol in mammalian biology. It constitutes 20-25% of the plasma membrane's structural components and is essential for regulating the fluidity and permeability of the membrane, influencing the behavior of transporters and signaling proteins. This compound also acts as an endogenous agonist for estrogen-related receptor α (ERRα), making it valuable for studies in cell membrane dynamics and receptor signaling in various biological contexts. -
Stable Isotope
3,4-Dihydroxybenzeneacetic acid-d5 is a deuterated stable isotope of 3,4-Dihydroxybenzeneacetic acid, which serves as a primary neuronal metabolite of dopamine. This labeled compound is essential for studying dopamine metabolism and its related pathways in neurological research. It provides valuable insights into the dynamics of neurotransmitter activity and can be utilized in various analytical techniques, including mass spectrometry and nuclear magnetic resonance spectroscopy. -
Stable Isotope
L-Alanine-d3 is a stable isotope of the non-essential amino acid L-Alanine, distinguished by the presence of deuterium. This compound plays a vital role in metabolic processes, particularly in sugar and acid metabolism. L-Alanine-d3 is utilized in various research applications, including studies of metabolic pathways, amino acid transport, and the tracing of metabolic processes in biological systems. Its incorporation into research provides enhanced analytical accuracy in understanding amino acid dynamics and energy production in tissues. -
Stable Isotope
Indole-d7 is a deuterium-labeled derivative of indole, serving as a stable isotope in chemical research. As an endogenous metabolite, indole plays a crucial role in various biological processes, including neurotransmitter synthesis and tryptophan metabolism. Indole-d7 is primarily utilized in mass spectrometry and other analytical techniques for metabolic tracing and studying metabolic pathways. Its isotopic labeling aids in quantifying concentrations and analyzing the kinetics of indole-related biological effects. -
Stable Isotope
p-Cresol sulfate-d7 potassium is a deuterium-labeled derivative of p-Cresyl sulfate, a known protein-bound uremic toxin. This stable isotope is utilized in metabolic studies and pharmacokinetic research to trace the behavior of p-Cresyl sulfate in biological systems. Its incorporation into research enables enhanced understanding of protein binding and uremic toxicity in clinical settings. -
Stable Isotope
Taurocholic acid-d4 sodium is a deuterium-labeled derivative of taurocholic acid, a bile acid primarily involved in the emulsification of dietary fats. This stable isotope is valuable for research applications, particularly in metabolic studies and tracer experiments that investigate lipid digestion and absorption. It can be utilized in mass spectrometry and other analytical techniques to trace metabolic pathways and quantify bile acid levels in biological samples. -
Stable Isotope
p-Coumaric acid-d6 is a deuterium-labeled derivative of p-Coumaric acid, a prominent isomer of cinnamic acid. This compound exhibits notable antitumor and anti-mutagenic properties, making it valuable for cancer research and mutagenesis studies. Its stable isotope labeling facilitates quantitative analysis and metabolic tracking in biochemical research applications. -
Stable Isotope
L-Threonine-13C4 is a stable isotope-labeled form of the amino acid L-Threonine. As a naturally occurring amino acid, L-Threonine plays a critical role in protein synthesis and is utilized widely in biochemical research. This stable isotope can be employed in metabolic studies, tracer experiments, and quantitative analyses to track metabolic pathways and protein dynamics in various biological systems. -
Stable Isotope
L-Tryptophan-d8 is a deuterium-labeled form of the essential amino acid L-Tryptophan, serving as a stable isotope for various research applications. It is a precursor to important biomolecules such as serotonin, melatonin, and vitamin B3. This reagent is valuable in metabolic studies, isotopic labeling experiments, and investigations of amino acid metabolism, aiding in the understanding of biological processes and drug development. -
Stable Isotope
L-Serine-d3 is a deuterium-labeled form of the non-essential amino acid L-Serine, which plays a crucial role in cellular proliferation and metabolic processes. This stable isotope is useful in research applications involving metabolic tracing and NMR spectroscopy. L-Serine-d3 allows for enhanced detection and quantification in various biochemical studies, thereby aiding in the understanding of amino acid metabolism and related pathways. -
Stable Isotope
i-Inositol-d6 is a deuterium-labeled form of i-Inositol, a naturally occurring compound involved in various biological processes. It serves as an important precursor for inositol phosphates and plays a critical role in cell signaling and membrane formation. This stable isotope is widely used in metabolic studies and tracer experiments to investigate cellular pathways and lipid metabolism. -
Stable Isotope
Estradiol-d5 is a deuterium-labeled derivative of estradiol, a steroid sex hormone essential for female fertility and the development of secondary sexual characteristics. This stable isotope serves as a valuable tool in research applications, particularly in metabolic studies and hormone tracking. Estradiol-d5 activates the estrogen receptor β (ERβ) pathway, leading to the upregulation of IL-6 expression, making it useful for investigating estrogen-related biological processes. -
Stable Isotope
Glutaric acid-d6 is a stable isotope-labeled form of glutaric acid, an important intermediate in the catabolic pathways of lysine and tryptophan. It plays a significant role in modulating pericyte contractility and migration, making it relevant for studies in cellular dynamics and pathology. Additionally, glutaric acid is an important biomarker for diagnosing glutaric aciduria type I, facilitating research in metabolic disorders. -
Stable Isotope
1-Methyl-L-histidine-d3 is a deuterium-labeled form of 1-Methyl-L-histidine, utilized as a stable isotope in metabolic studies. This compound serves as a valuable biomarker for quantifying meat consumption and the intake of exogenous 3-methylhistidine (3MH). Researchers can apply this reagent in dietary assessments and metabolic tracing to better understand protein turnover and the physiological effects of meat-derived amino acids. -
Stable Isotope
Hippuric acid-d2 is the deuterium-labeled form of hippuric acid, a stable isotope used in various analytical applications. As a metabolite of aromatic compounds, it plays a key role in studies involving metabolic pathways and biochemistry. Its incorporation in research can enhance the accuracy of metabolic profiling and pharmacokinetic studies, providing insights into the metabolism of aromatic substances in biological systems. -
Stable Isotope
L-Citrulline-d4 is the deuterium-labeled analog of the amino acid L-Citrulline, which plays a critical role in the urea cycle and the production of nitric oxide. This stable isotope is utilized in metabolic studies and pharmacokinetic research to trace metabolic pathways involving citrulline. Its applications include investigating amino acid metabolism and exploring nitric oxide-mediated physiological processes. -
Stable Isotope
L-Serine-13C is a stable isotope-labeled form of L-Serine, an amino acid fundamental to various biological processes. It plays a critical role in cellular proliferation and is involved in the synthesis of proteins and neurotransmitters. This reagent is particularly useful for metabolic studies, isotopic tracing experiments, and research related to amino acid metabolism. -
Stable Isotope
DEHP-d4 is a deuterated form of bis(2-ethylhexyl) phthalate (DEHP), serving as a stable isotope. This compound is utilized in biological studies to trace and quantify metabolic pathways involving DEHP, an endogenous metabolite. Its incorporation into research allows for enhanced accuracy in the analysis of phthalate exposure and its effects on biological systems. -
Stable Isotope
p-Tyramine-d4 hydrochloride is a deuterium-labeled variant of tyramine hydrochloride, which serves as a stable isotope for analytical applications. This compound is involved in the regulation of blood pressure and is naturally occurring in various foods and biological systems. It can be utilized in metabolic studies and tracing experiments to elucidate the role of tyramine in physiological processes. -
Stable Isotope
L-Aspartic acid-15N is a stable isotope-labeled form of the amino acid L-Aspartic acid. This compound plays a crucial role in various metabolic processes and is known for its ability to penetrate the blood-brain barrier. L-Aspartic acid-15N is primarily applied in the development of prodrugs targeting colon and cecal tissues and is also utilized in research related to inflammatory conditions. Its isotopic labeling allows for advanced studies in metabolic tracking and related biochemical pathways. -
Stable Isotope
Cinnamic acid-d6 is a deuterium-labeled derivative of cinnamic acid, serving as a stable isotope for analytical studies. Cinnamic acid is recognized for its potential anti-cancer properties, exhibiting IC50 values between 1-4.5 mM in various cancer cell lines, including glioblastoma, melanoma, prostate, and lung carcinoma. This compound is valuable for research applications that require tracking metabolic pathways, studying drug interactions, and understanding the mechanisms of action in cancer biology. -
Stable Isotope
L-Serine-d7 is a deuterated form of the non-essential amino acid L-Serine, serving as a stable isotope labeled compound. L-Serine is vital for cellular processes, including proliferation and metabolism. This reagent is primarily utilized in metabolic studies, tracer experiments, and proteomic analyses, enhancing the understanding of amino acid metabolism and biological pathways.
