Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
(1R,3S-)Solifenacin-d5 hydrochloride is a deuterated form of Solifenacin hydrochloride, a potent muscarinic receptor antagonist. It exhibits significant binding affinity with pKis of 7.6, 6.9, and 8.0 for M1, M2, and M3 receptors, respectively. This stable isotope is valuable for use in pharmacokinetic studies and metabolic research, facilitating the investigation of drug metabolism and receptor interactions. -
Stable Isotope
Flavoxate-d4 hydrochloride is a deuterated form of Flavoxate hydrochloride, acting as a muscarinic acetylcholine receptor antagonist. It is utilized in the study of urinary disorders and exhibits antispasmodic properties. This stable isotope is particularly useful in pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of the compound in various biological systems. -
Stable Isotope
(R)-Hydroxytolterodine-d14 is a deuterated form of Desfesoterodine, a selective antagonist of muscarinic acetylcholine receptors (mAChRs). This compound exhibits high potency, with a KB value of 0.84 nM and a pA2 of 9.14. As a significant metabolite of Tolterodine and Fesoterodine, it has demonstrated efficacy in models of cerebral infarction-induced detrusor overactivity in rats, making it valuable for research in urology and neurology. -
Stable Isotope
Ethyl linolenate-d5 is the deuterium-labeled form of Ethyl linolenate, a fatty acid ethyl ester. This compound is known for its ability to inhibit melanin production, demonstrating an IC50 value of 70 μM. It is primarily utilized in research applications focused on melanogenesis and can serve as a valuable tool in studying pigmentation processes and related disorders. -
Stable Isotope
Ramelteon metabolite M-II-d3 is a deuterium-labeled derivative of the major metabolite M-II of Ramelteon, a selective agonist of melatonin receptors (MT1 and MT2). This reagent exhibits significant biological activity, with IC50 values of 208 pM and 1470 pM for human MT1 and MT2 receptors, respectively. It is primarily used in pharmacological studies and metabolic research involving melatonin signaling pathways. -
Stable Isotope
Ramelteon-d5 is a deuterated form of Ramelteon, a highly selective and potent agonist of the MT1 and MT2 melatonin receptors, exhibiting Ki values of 14 pM and 112 pM, respectively. This stable isotope is valuable for research studies focusing on insomnia and sleep disorders, as Ramelteon has demonstrated efficacy in reducing sleep onset during long-term treatment without leading to next-morning residual effects or withdrawal symptoms upon discontinuation. Researchers can utilize Ramelteon-d5 in pharmacokinetic and metabolic studies to gain insights into the compound's mechanism and therapeutic potential. -
Stable Isotope
Tasimelteon-d5 is a deuterium-labeled derivative of Tasimelteon, a selective dual melatonin receptor agonist targeting MT1 and MT2 receptors. This compound exhibits significantly higher affinity for the MT2 receptor, with an affinity range of 2.1-4.4 times greater than that for the MT1 receptor. Tasimelteon serves as a circadian regulator and is being investigated for its potential therapeutic applications in managing Non-24-Hour Sleep-Wake Disorder (Non-24). -
Stable Isotope
Ramelteon-d3 is a deuterium-labeled derivative of Ramelteon, a highly selective and orally active agonist of melatonin receptors MT1 and MT2, exhibiting Ki values of 14 pM and 112 pM, respectively. This stable isotope is utilized in pharmacokinetic studies and research applications focused on insomnia, providing insight into sleep modulation mechanisms. Ramelteon is known for its efficacy in reducing sleep onset without causing residual effects, rebound insomnia, or withdrawal symptoms with long-term use. -
Stable Isotope
O-Phospho-L-serine-13C3,15N is a stable isotope-labeled form of O-Phospho-L-serine, which serves as the immediate precursor to L-serine in the serine biosynthesis pathway. This compound functions as an agonist at group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, and mGluR8) and exhibits weak antagonistic properties at mGluR1 while acting as a potent antagonist at mGluR2. Its unique isotopic labeling makes it valuable for metabolic and neurobiological research, particularly in studies involving neurotransmitter signaling and cellular metabolism. -
Stable Isotope
O-Phospho-L-serine-13C3 is a stable isotope-labeled form of O-Phospho-L-serine, serving as a valuable tool in metabolic studies. As an immediate precursor to L-cysteine in the serine synthesis pathway, it plays a critical role in amino acid metabolism. This compound also acts as an agonist for group III metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7, and mGluR8) while exhibiting weak antagonistic properties at mGluR1 and potent antagonism at mGluR2. Its isotopic labeling makes it suitable for tracing and quantifying metabolic pathways in research applications. -
Stable Isotope
Netupitant-d6 is a deuterated derivative of Netupitant, a highly potent and selective neurokinin-1 (NK1) receptor antagonist. This stable isotope is utilized in various biochemical and pharmacological studies to investigate the mechanisms of action and metabolic pathways of NK1 receptor inhibitors. Its application in research facilitates the analysis of drug behavior, distributions, and interactions within biological systems. -
Stable Isotope
Maropitant-d3 is a deuterium-labeled derivative of Maropitant, a selective neurokinin (NK1) receptor antagonist. This compound functions by inhibiting the binding of substance P in the emetic center and the chemoreceptor trigger zone (CRTZ), showcasing significant efficacy in the prevention of vomiting. Maropitant-d3 is valuable in chemical research requiring stable isotopes for the study of pharmacokinetics and metabolism of NK1 receptor antagonists. -
Stable Isotope
Riociguat-d3 is a deuterium-labeled derivative of Riociguat, a potent oral stimulator of soluble guanylate cyclase (sGC). This stable isotope is utilized primarily in research applications focusing on the pharmacokinetics and metabolic pathways of Riociguat. Its unique labeling allows for advanced analytical studies and enhances understanding of sGC's role in the treatment of pulmonary hypertension. -
Stable Isotope
Leukotriene B4-d4 is a deuterium-labeled analog of Leukotriene B4 (LTB4), a potent chemoattractant for leukocytes that plays a significant role in inflammatory responses. This stable isotope can be utilized in research to trace LTB4 in biological systems, enhancing the understanding of its involvement in various inflammatory diseases. Additionally, LTB4 serves as an alkyl chain-based linker in the development of PROTACs, facilitating targeted protein degradation studies. -
Stable Isotope
Montelukast-d6 sodium is a deuterium-labeled form of Montelukast, a potent and selective oral antagonist of the cysteinyl leukotriene receptor 1 (Cysltr1). This reagent is crucial for research applications focused on asthma and liver injury, offering insights into leukotriene signaling pathways. Additionally, Montelukast-d6 sodium exhibits antioxidant properties, making it relevant for studies on intestinal ischemia-reperfusion injury and the mitigation of cardiac damage. -
Stable Isotope
Montelukast-d6 is a deuterated form of Montelukast, a selective antagonist of the cysteinyl leukotriene receptor 1 (CysLTR1). This stable isotope is utilized in research to investigate the pharmacokinetics and metabolic pathways of Montelukast, particularly in the contexts of asthma and liver injury. Additionally, Montelukast has demonstrated antioxidant properties in models of intestinal ischemia-reperfusion injury and has potential applications in studying cardiac damage. -
Stable Isotope
Pranlukast-d4 is a deuterated form of Pranlukast, which selectively and competitively antagonizes peptide leukotrienes. This stable isotope demonstrates high potency in inhibiting bindings of [3H]LTE4, [3H]LTD4, and [3H]LTC4 to lung membranes, with inhibition constants of 0.63±0.11 nM, 0.99±0.19 nM, and 5640±680 nM, respectively. Pranlukast-d4 is valuable for pharmacokinetic studies and metabolic profiling in research related to asthma and allergic conditions. -
Stable Isotope
Zafirlukast-d7 is a deuterated derivative of Zafirlukast, a selective antagonist of leukotriene D4 (LTD4) receptors. This stable isotope compound is utilized in biological research to trace and quantify Zafirlukast’s pharmacokinetics and metabolic processes in various systems. Its applications extend to studying therapeutic mechanisms in asthma, inflammation, and other related pathological conditions. -
Stable Isotope
Zafirlukast-d6 is a deuterated labeled form of Zafirlukast, a potent orally active antagonist of the leukotriene D4 (LTD4) receptor. This compound exhibits significant anti-asthmatic, anti-inflammatory, and anti-bacterial properties, making it valuable in respiratory disease research. Zafirlukast-d6 is utilized as a stable isotope for advanced analytical studies, enabling the investigation of metabolic pathways and pharmacokinetics of leukotriene receptor antagonists in biological systems. -
Stable Isotope
Sphingosine-1-phosphate-d7 is a deuterium-labeled analog of Sphingosine-1-phosphate (S1P), a well-established agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, and GPR12. As a key intracellular second messenger, S1P plays a crucial role in mobilizing Ca2+ and mediating various physiological responses. This stable isotope is valuable for studying lipid signaling pathways, receptor interactions, and the metabolic fate of S1P in biochemical assays. -
Stable Isotope
Sphingosylphosphorylcholine-d7 is a deuterium-labeled analog of Sphingosylphosphorylcholine, used as a stable isotope for analytical studies. This reagent is valuable for research applications involving lipid signaling and sphingolipid metabolism. Its stability and isotopic labeling facilitate advanced quantification and tracking of sphingolipid pathways in cellular processes. -
Stable Isotope
Siponimod-d11 is a deuterium-labeled derivative of Siponimod, a selective modulator of sphingosine-1-phosphate (S1P) receptors. This compound exhibits preferential binding to the S1P1 and S1P5 receptors with EC50 values of 0.4 and 0.98 nM, respectively, while showing significantly lower affinity for S1P2, S1P3, and S1P4. Siponimod-d11 is a valuable tool in the research of multiple sclerosis, aiding in the understanding of S1P receptor signaling and its therapeutic implications. -
Stable Isotope
2-Acetyl-4-tetrahydroxybutyl imidazole-13C6 is a stable isotope-labeled version of 2-Acetyl-4-tetrahydroxybutyl imidazole, serving as a potent inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo. This compound is particularly useful for metabolic studies and tracing experiments in biological research. Researchers can utilize this isotope-labeled reagent to investigate the dynamics of sphingolipid metabolism and explore the roles of S1P in various physiological and pathological processes. -
Stable Isotope
Fingolimod phosphate-d4 is a deuterium-labeled form of FTY720 phosphate, serving as a stable isotope label. This compound is utilized in pharmacokinetic studies and metabolic research to trace the biochemical pathways of Fingolimod, a sphingosine-1-phosphate receptor modulator. Its isotopic labeling enables precise measurement and analysis of drug metabolism and distribution in biological systems. -
Stable Isotope
(Rac)-Atropine-d3 is a deuterium-labeled analog of atropine, serving as a stable isotope reagent. It primarily targets the muscarinic acetylcholine receptors, influencing various physiological processes. This compound is valuable for studies related to pharmacokinetics and metabolic labeling, enabling precise tracing and quantification in biological systems. -
Stable Isotope
Tiotropium-d6 bromide is a deuterium-labeled analogue of Tiotropium, primarily targeting muscarinic acetylcholine receptors (mAChR). As a potent mAChR antagonist, it effectively inhibits the binding of acetylcholine, preventing the activation of ligand-gated ion channels. This reagent is valuable for studies involving receptor binding assays, pharmacokinetics, and metabolic pathway analysis. -
Stable Isotope
Propantheline-d3 bromide is a deuterium-labeled version of Propantheline bromide, an antimuscarinic agent that primarily targets muscarinic acetylcholine receptors. It exhibits key biological activities in the inhibition of involuntary muscle contractions, making it effective for managing conditions such as hyperhidrosis, gastrointestinal cramps, bladder spasms, and enuresis. This stable isotope is useful in pharmacokinetic studies and tracer applications in research. -
Stable Isotope
Xanomeline-d3 is a deuterated form of Xanomeline that selectively targets muscarinic type 1 and type 4 (M1/M4) receptors. As an effective agonist, it enhances neuronal excitability, making it a valuable tool in the study of neurological disorders, including schizophrenia. This stable isotope can be utilized in metabolic and pharmacokinetic research applications to trace and quantify Xanomeline metabolism in biological systems. -
Stable Isotope
Tropicamide-d3 is a deuterium-labeled derivative of Tropicamide, which functions as a selective antagonist of the M4 muscarinic acetylcholine receptor. This compound is primarily utilized for its ability to induce short-acting mydriasis and cycloplegia when administered as eye drops. It serves as a valuable tool in neurological and pharmacological research, particularly in studies investigating cholinergic signaling and receptor pharmacodynamics. -
Stable Isotope
Oxybutynin-d11 chloride is the deuterated form of Oxybutynin chloride, an anticholinergic agent primarily targeting vascular Kv channels. This compound exhibits concentration-dependent inhibition, with an IC50 of 11.51 μM. Oxybutynin-d11 chloride is useful for studies in pharmacokinetics, metabolic profiling, and isotopic tracing in chemical research. -
Stable Isotope
(Rac)-5-Hydroxymethyl Tolterodine-d14 is a deuterium-labeled derivative of (Rac)-5-Hydroxymethyl Tolterodine, a potent muscarinic acetylcholine receptor (mAChR) antagonist. It exhibits high affinity with Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively. This stable isotope is instrumental in studies related to overactive bladder syndrome and facilitates pharmacokinetic research by enabling sensitive detection and quantification in biological samples. -
Stable Isotope
Tiotropium-d3 bromide is a deuterium-labeled variant of Tiotropium bromide, a selective antagonist of muscarinic acetylcholine receptors (mAChRs). By inhibiting acetylcholine binding, it prevents the opening of ligand-gated ion channels, leading to bronchial dilation. This compound is primarily used in pharmacological studies related to respiratory disorders and can be utilized in isotopic labeling experiments to investigate drug metabolism and pharmacokinetics. -
Stable Isotope
Darifenacin-d4 is a deuterium-labeled derivative of Darifenacin, which acts as a selective antagonist for the M3 muscarinic receptor, exhibiting a pKi value of 8.9. This stable isotope compound is valuable for pharmacokinetic studies and metabolic research, allowing for precise tracking of the parent compound and its metabolites in biological systems. Its use in isotope labeling enhances analytical techniques such as mass spectrometry in studying receptor interactions and drug metabolism. -
Stable Isotope
Pirenzepine-d8 dihydrochloride is a deuterium-labeled derivative of Pirenzepine, a selective antagonist of the M1 muscarinic acetylcholine receptor (mAChR). This compound exhibits significant biological activity by inhibiting gastric acid secretion and alleviating muscle spasms, making it valuable for research in peptic ulcers. Additionally, Pirenzepine-d8 demonstrates anti-proliferative effects in cancer cell lines, contributing to its use in cancer research applications. -
Stable Isotope
(Rac)-Tolterodine-d5 is a deuterium-labeled analogue of (rac)-Tolterodine, a muscarinic receptor antagonist. This stable isotope-labeled compound is primarily used in pharmacokinetic studies, allowing for the tracking of drug metabolism and bioavailability in biological systems. Its deuterium label enhances molecular stability, making it an essential tool in drug development and metabolic research. -
Stable Isotope
Pilocarpine-d3 hydrochloride is a deuterium-labeled derivative of Pilocarpine hydrochloride, functioning as a selective agonist for the M3 muscarinic acetylcholine receptor. This stable isotope is employed in various biological research applications, including pharmacokinetic studies and metabolic tracking of cholinergic signaling pathways. Its ability to activate M3 muscarinic receptors makes it valuable for understanding aspects of neurotransmission and receptor pharmacology. -
Stable Isotope
(Rac)-5-Hydroxymethyl tolterodine-d5 is a deuterated analog of (Rac)-5-Hydroxymethyl Tolterodine, functioning as a stable isotope for research applications. This compound serves as a useful tool in pharmacokinetic and metabolic studies, allowing for the tracking of drug disposition and dynamics in biological systems. Its isotopic labeling facilitates enhanced accuracy in quantitative analyses, making it valuable for studies in drug development and metabolism. -
Stable Isotope
Pirenzepine-d8 is a deuterated form of Pirenzepine dihydrochloride, functioning as a selective antagonist of the M1 muscarinic receptor. This stable isotope labeling facilitates advanced biochemical analyses and studies of muscarinic receptor signaling pathways. It is particularly useful in pharmacokinetic studies, providing insights into drug interactions and receptor dynamics. -
Stable Isotope
(±)-Darifenacin-d4 hydrobromide is a deuterium-labeled derivative of (±)-Darifenacin, which serves as a selective antagonist of the M3 muscarinic receptor. This stable isotope is useful in pharmacokinetic studies and can aid in elucidating the metabolic pathways of (±)-Darifenacin. Its unique labeling allows for precise tracking in biological assays and enhances the understanding of drug interactions and mechanisms of action. -
Stable Isotope
Fesoterodine-d7 fumarate is a deuterium-labeled derivative of Fesoterodine fumarate, serving as a stable isotope for research applications. Fesoterodine fumarate acts as a competitive antagonist of muscarinic acetylcholine receptors (mAChRs), demonstrating non-subtype selectivity with pKi values of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5, respectively. It is primarily utilized in studies related to overactive bladder (OAB) and provides valuable insight into muscarinic receptor function and pharmacology. -
Stable Isotope
(Rac)-Tolterodine-d14 tartrate is a stable isotope-labeled derivative of (Rac)-Tolterodine tartrate, featuring deuterium substitutions. This compound is utilized primarily in pharmacokinetic studies and can facilitate the investigation of drug metabolism and pharmacodynamics. Its isotopic labeling enables enhanced sensitivity and accuracy in analytical techniques such as mass spectrometry. -
Stable Isotope
Fesoterodine-d3 is a deuterium-labeled derivative of Fesoterodine, functioning as a competitive antagonist of muscarinic acetylcholine receptors (mAChRs). It exhibits non-subtype selective activity, with pKi values of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5 receptors, respectively. This reagent is primarily utilized in research related to overactive bladder (OAB) and studies involving receptor pharmacology. Its stable isotope form aids in biochemical assays and metabolic studies. -
Stable Isotope
Quifenadine-d10 is a stable isotope-labeled form of Quifenadine, a hydroxyl-(diphenyl)methyl quinuclidine derivative. As an M3 receptor antagonist, Quifenadine exhibits an IC50 value greater than 1000 nM. This compound is utilized in research related to neurological diseases, enabling insights into receptor interactions and mechanisms of action within the central nervous system. -
Stable Isotope
(±)-Darifenacin-d4 is a deuterium-labeled derivative of (±)-Darifenacin, a selective M3 muscarinic receptor antagonist. This stable isotope is utilized in pharmacokinetic studies and metabolic research to track the absorption, distribution, metabolism, and excretion of the parent compound. Its application in isotopic labeling allows for enhanced sensitivity in analytical techniques such as mass spectrometry. -
Stable Isotope
Arecoline-d5 hydrobromide is a deuterated form of the psychoactive alkaloid Arecoline, functioning as a partial agonist at nicotinic and muscarinic acetylcholine receptors. This reagent is useful for studying the compound's biological activity, including its stimulating, anxiolytic, and anti-parasitic effects. As a stable isotope, Arecoline-d5 hydrobromide can aid in tracing and quantifying metabolic pathways in pharmacological research, particularly in investigations of oxidative stress induction. -
Stable Isotope
Tolterodine-d14 hydrochloride is a deuterium-labeled version of Tolterodine hydrochloride, a potent muscarinic acetylcholine receptor (mAChR) inhibitor. This compound competitively binds to acetylcholine, thereby reducing involuntary bladder muscle contractions and modulating sympathetic nervous activity. In addition to its role in managing overactive bladder and urinary tract infections, Tolterodine has been shown to restore the Nrf2/NF-κB signaling pathway, offering protective effects against inflammation and ferroptosis. Its applications extend to studies involving reactive oxygen species and lipid oxidation. -
Stable Isotope
Z-Doxepin-d3 Hydrochloride is a deuterated stable isotope of the active metabolite 7-Hydroxychlorpromazine hydrochloride, known for its dopaminergic activity. This compound enhances prolactin levels and dopaminergic turnover, leading to sedative effects in animal models. It is utilized in research focusing on psychosis and the modulation of amphetamine-induced stereotypic behaviors in rats, making it a valuable tool for studying neuropharmacological mechanisms. -
Stable Isotope
Itopride-d6 hydrochloride is a deuterium-labeled derivative of Itopride hydrochloride that serves as a stable isotope. Itopride functions as a gastroprokinetic agent by inhibiting acetylcholinesterase (AChE) and antagonizing dopamine D2 receptors. This compound is valuable for studies investigating gastrointestinal motility and neurotransmitter interactions, as well as for tracing and quantifying its metabolic pathways in biological research. -
Stable Isotope
Desmethyl cariprazine-d8 is a deuterium-labeled analog of desmethyl cariprazine, a prominent active metabolite of cariprazine. This compound demonstrates significant affinity for human dopamine D2 and D3 receptors, with pEC50 values of 8.90 and 8.09, respectively, as well as a pEC50 of 6.28 at serotonin 5-HT1A receptors. Desmethyl cariprazine-d8 effectively inhibits forskolin-induced cAMP production and suppresses serotonin-induced Ca2+ release at the 5-HT2B receptor. Its utility is particularly relevant in research focused on mental health disorders such as schizophrenia and bipolar disorder type I. -
Stable Isotope
Dexpramipexole-d3 dihydrochloride is a deuterium-labeled derivative of Dexpramipexole, which acts as a neuroprotective agent and a weak non-ergoline dopamine agonist. This stable isotope is useful in tracing studies and pharmacokinetic investigations, allowing researchers to monitor drug metabolism and distribution. Its applications extend to studies focusing on neurodegenerative diseases and the modulation of dopaminergic pathways in various biological contexts.
