Isotope-Labeled Compounds

Miglustat-d9 hydrochloride is a deuterated form of Miglustat hydrochloride, functioning as an inhibitor of glucosylceramide synthase. This compound demonstrates significant biological activity in the modulation of glycosphingolipid metabolism, making it valuable for research related to Type I Gaucher disease (GD1). Its stable isotope labeling allows for enhanced metabolic tracing studies and investigations into enzyme activity in cellular systems.

Miglustat-d9 is a deuterated form of Miglustat, which functions as a selective inhibitor of glucosylceramide synthase. This compound is primarily utilized in the study of Type I Gaucher disease (GD1) and serves as a valuable stable isotope in metabolic research. Its unique deuterium labeling enables advanced analytical applications, aiding in the investigation of metabolic pathways and drug metabolism.

Hydroxylamine-d3 hydrochloride is a deuterium-labeled derivative of hydroxylamine hydrochloride, serving as a selective inhibitor of monoamine oxidase (MAO). This compound is utilized in studies assessing platelet aggregation and plays a role in the nitrogen cycle, particularly among ammonium-oxidizing microorganisms, including ammonium oxidizing bacteria (AOB) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine-d3 hydrochloride is instrumental in investigating the effects of microbial activity on nitrogen oxide emissions and the suppression of nitrite-oxidizing bacteria (NOB).

Safinamide-d4-1 is a deuterium-labeled derivative of Safinamide, a selective and reversible inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 0.098 μM, demonstrating significantly lower inhibition of MAO-A (IC50=580 μM). In addition to its MAO-B inhibitory activity, Safinamide also interacts with sodium channels and modulates glutamate release, exhibiting a greater affinity at depolarized potentials (IC50=8 μM) compared to resting potentials (IC50=262 μM). This reagent is valuable for research applications related to neurobiology, particularly in the investigation of Parkinson's disease and ischemic stroke mechanisms.

Hydroxylamine-15N hydrochloride is a stable isotope-labeled variant of Hydroxylamine hydrochloride, primarily recognized for its role as a selective inhibitor of Monoamine oxidase (MAO). This compound is employed in the study of platelet aggregation and serves as an important intermediate in the nitrogen cycle, particularly in aerobic ammonium-oxidizing microorganisms, including ammonium-oxidizing bacteria (AOB), ammonium-oxidizing archaea (AOA), and complete ammonium oxidizing bacteria (comammox). Additionally, it plays a critical role in research focused on nitrogen oxide (NO) and nitrous oxide (N2O) emissions while inhibiting the activity of nitrite-oxidizing bacteria (NOB).

Moclobemide-d8 is a deuterated form of Moclobemide, a reversible inhibitor of monoamine oxidase A (MAO-A) with an IC50 of 6.061 μM for human MAO-A. This compound effectively penetrates the blood-brain barrier and has been shown to promote the proliferation of hippocampal progenitor cells in models of chronic stress. Moclobemide-d8 is particularly useful in pharmacokinetic studies and metabolic research involving MAO-A modulation.

Selegiline-d5 is a deuterium-labeled derivative of Selegiline, targeting the selective and irreversible inhibition of monoamine oxidase B (MAO-B) with an IC50 of 51 nM. This compound demonstrates a 450-fold selectivity for MAO-B over MAO-A (IC50=23 µM). Selegiline-d5 is valuable for research into neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, as well as in the investigation of major depressive disorder.

Selegiline-d5 hydrochloride is a deuterium-labeled form of the irreversible monoamine oxidase B (MAO-B) inhibitor, Selegiline. This compound exhibits a high selectivity for MAO-B with an IC50 of 51 nM, demonstrating 450-fold preference over MAO-A (IC50 = 23 μM). Selegiline-d5 hydrochloride is utilized in research related to neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, and major depressive disorder, providing valuable insights into the biochemical pathways involved in these conditions.

Fluoxetine-d5 hydrochloride is a deuterated analog of Fluoxetine hydrochloride, serving as a stable isotope. It is primarily utilized in pharmacokinetic studies and metabolic tracing, allowing for the investigation of drug metabolism and pharmacodynamics in biological systems. This reagent is critical for research exploring the biochemical pathways and therapeutic effects associated with selective serotonin reuptake inhibitors (SSRIs).

Venlafaxine-d6 is a deuterium-labeled derivative of Venlafaxine, a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is utilized in pharmacokinetic studies to trace the metabolism and distribution of Venlafaxine in biological systems. Its applications extend to evaluating the pharmacological profile of this antidepressant in research settings.

(±)-cis-Sertraline-d3 hydrochloride is a deuterated form of Sertraline hydrochloride, acting as a selective serotonin reuptake inhibitor (SSRI). This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research involving antidepressants. Its applications extend to investigations of major depressive disorder and obsessive-compulsive disorder, providing insights into the drug's mechanism of action and therapeutic effectiveness.

Venlafaxine-d6 hydrochloride is a stable isotope-labeled form of the antidepressant Venlafaxine hydrochloride, functioning as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This reagent is primarily used in pharmacokinetic studies and metabolic research to trace the pharmacological behavior of Venlafaxine in biological systems. Its deuterium labeling aids in enhancing the sensitivity and specificity of analytical methods, providing valuable insights into drug metabolism and biochemical pathways.

rel-Sertraline-d3 hydrochloride is a deuterated form of Sertraline hydrochloride, targeting the selective serotonin reuptake inhibitor (SSRI) mechanism. This stable isotope is utilized in pharmacokinetic studies to trace metabolic pathways and quantify drug concentrations in biological samples. Research applications include investigations into major depressive disorder, obsessive-compulsive disorder, and other serotonin-related disorders.

Duloxetine-d7 is the deuterated form of Duloxetine, a potent serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. This labeled compound is utilized in pharmacokinetic studies and metabolic research related to major depressive disorder and generalized anxiety disorder (GAD). Its stable isotope labeling provides valuable insights into the drug's metabolic pathways and pharmacological mechanisms.

Clomipramine-d6 hydrochloride is a deuterated form of Clomipramine hydrochloride, primarily acting as a potent inhibitor of serotonin (5-HT) reuptake, with an IC50 value of 1.5 nM. This stable isotope is valuable for research applications in depression and obsessive-compulsive disorder (OCD). Its deuterated nature enables precise quantification and tracing in metabolic studies, facilitating a better understanding of these psychiatric conditions and the pharmacodynamics of tricyclic antidepressants.

Dapoxetine-d6 is a deuterium-labeled form of Dapoxetine, a selective serotonin reuptake inhibitor (SSRI). This stable isotope is utilized in pharmacokinetic studies and metabolic research. Dapoxetine is primarily researched for its effectiveness in treating premature ejaculation (PE), making Dapoxetine-d6 an essential tool for understanding its biological mechanisms and enhancing drug development in this area.

Dapoxetine-d7 is a deuterated form of the selective serotonin reuptake inhibitor (SSRI) Dapoxetine. Its primary mechanism involves the inhibition of serotonin reuptake, which enhances serotonergic signaling. This stable isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research related to premature ejaculation (PE), providing insights into the drug's pharmacological properties and behaviors in biological systems.

Dextromilnacipran-d6 is a deuterium-labeled analog of Dextromilnacipran, a selective serotonin and norepinephrine (5-HT/NE) reuptake inhibitor. This compound also acts as a human alpha-adrenergic receptor antagonist, exhibiting an IC50 of 3.4 μM. Dextromilnacipran-d6 is a valuable tool for metabolic and pharmacokinetic studies, providing insights into the behavior and efficacy of 5-HT/NE reuptake inhibitors in various research contexts.

Dapoxetine-d6 hydrochloride is a stable isotope-labeled form of Dapoxetine hydrochloride, a short-acting selective serotonin reuptake inhibitor (SSRI). This deuterated compound is primarily used in pharmacokinetic studies to trace the metabolic pathways of Dapoxetine. Its applications include drug metabolism research and studies assessing serotonin modulation in various biological systems.

Venlafaxine-d6-1 is a deuterium-labeled derivative of Venlafaxine, a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace and quantify the drug's behavior in biological systems. Venlafaxine is primarily used as an antidepressant, making this labeled compound valuable for investigating its mechanism of action and therapeutic effects.

Desvenlafaxine-d10 is a deuterated version of Desvenlafaxine, which is the active metabolite of Venlafaxine. It functions primarily as a selective inhibitor of the serotonin and norepinephrine transporters (5-HT and NET), demonstrating IC50 values of 47.3 nM and 531.3 nM, respectively. This compound is utilized in pharmacokinetic studies and research involving neurotransmitter systems, given its ability to penetrate the blood-brain barrier and its limited interaction with the dopamine transporter, where it exhibits only weak inhibitory activity.

Desvenlafaxine-d6 is a deuterium-labeled derivative of Desvenlafaxine, which acts as a selective serotonin (5-HT) and norepinephrine reuptake inhibitor. It exhibits significant potency with IC50 values of 47.3 nM for the human serotonin transporter (hSERT) and 531.3 nM for the human norepinephrine transporter (hNET). Additionally, Desvenlafaxine shows minimal binding affinity at the human dopamine transporter, indicating its focused mechanism of action. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in neuropharmacology research.

Venlafaxine-d9 is a deuterated analog of Venlafaxine, functioning primarily as a stable isotope. This compound acts as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake, making it relevant for antidepressant research. Venlafaxine-d9 is employed in pharmacokinetic studies and metabolite tracking, enhancing our understanding of the pharmacodynamics and pharmacokinetics of its parent compound.

(E)-Fluvoxamine-d4 maleate is a deuterated analog of (E)-Fluvoxamine maleate, serving as a stable isotope tracer in pharmacokinetic studies. This compound is primarily utilized in research to investigate the pharmacological effects and metabolic pathways of (E)-Fluvoxamine. Its stable isotope labeling allows for enhanced detection and quantification in various biological assays, facilitating a deeper understanding of its biological activity and therapeutic potential.

Venlafaxine-d10 is a deuterium-labeled analog of the antidepressant venlafaxine, which functions as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is valuable for pharmacokinetic studies, enabling researchers to investigate the metabolism and biological activity of venlafaxine in various biological systems. Its applications are critical for understanding the pharmacological mechanisms underlying antidepressant effects and for developing improved therapeutic strategies.

Imipramine-d6 is the deuterium-labeled form of Imipramine hydrochloride, a tricyclic antidepressant that primarily acts as a serotonin transporter inhibitor with an IC50 value of 32 nM. It exhibits notable antitumor activity as a Fascin1 inhibitor, promoting autophagy in U-87MG glioma cells and inducing apoptosis in HL-60 cells. Additionally, Imipramine-d6 demonstrates neuroprotective and immunomodulatory effects, making it valuable for research into depression, cancer, and neurodegenerative disorders.

Citalopram-d4 hydrobromide is a deuterated form of the selective serotonin reuptake inhibitor (SSRI) Citalopram hydrobromide. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling to provide detailed information on drug metabolism and distribution. Its incorporation into research can enhance the understanding of serotonin-related pathways and support the development of therapeutic strategies for mood disorders.

Escitalopram-d6 oxalate is a deuterium-labeled derivative of the selective serotonin reuptake inhibitor (SSRI) escitalopram, specifically the S-enantiomer of racemic citalopram. It demonstrates a binding affinity of 0.89 nM, approximately 30 times higher than its R(-)-enantiomer, while maintaining selectivity for serotonin transporters over dopamine (DAT) and norepinephrine (NET) transporters. This reagent is utilized in research focused on the mechanisms of major depression and the pharmacokinetics of SSRIs.

Duloxetine-d5 oxalate is a deuterium-labeled derivative of Duloxetine, primarily acting as a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. This stable isotope is useful in pharmacokinetic studies and investigations of drug metabolism. Its unique isotopic labeling enables precise tracking and quantification in biological assays, making it valuable for research in psychiatric disorders such as major depressive disorder and generalized anxiety disorder.

Venlafaxine-d10 hydrochloride is a deuterium-labeled derivative of Venlafaxine hydrochloride, acting as a potent dual inhibitor of serotonin (5-HT) and norepinephrine (NE) reuptake. This stable isotope is utilized in pharmacokinetic studies to better understand the metabolism and distribution of Venlafaxine in biological samples. Its application extends to research involving antidepressant efficacy and neurochemical dynamics in the treatment of mood disorders.

Opipramol-d4 is a deuterium-labeled analog of Opipramol, serving as a stable isotope for biochemical applications. This isotopic modification enhances the study of Opipramol's pharmacokinetics and metabolic pathways. Opipramol-d4 is primarily used in research involving its antidepressant and anxiolytic properties, facilitating more precise tracking in experiments involving liquid chromatography and mass spectrometry.

9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate is a deuterated variant of CRBN ligand-74, functioning as a CRBN-type E3 ubiquitin ligase ligand. This stable isotope can be utilized in the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. Its unique deuterated structure enhances analytical applications and facilitates tracing in various biological research protocols.

Benzoin-d10 is a deuterium-labeled derivative of Benzoin, functioning as a stable isotope. It serves as a valuable tool in pharmacokinetic studies and metabolic research. The native compound exhibits anti-cancer properties, specifically acting as a PI3Kα inhibitor and demonstrating growth inhibition in colon cancer cell lines such as HCT-116. Benzoin-d10 can also be utilized in food additive applications, providing insights into food chemistry and safety assessments.

Triacetonamine-d17 is a deuterium-labeled form of Triacetonamine, serving as a stable isotope for various research applications. This compound is notable for its oral activity and potential to induce acute liver failure (ALF) in animal models, specifically in rats. It is relevant for studies investigating liver toxicity and metabolic pathways, providing a valuable tool for researchers exploring hepatic function and drug metabolism.

N-Methylpyrrolidone-d9 is a deuterated form of N-Methylpyrrolidone (NMP), a five-membered cyclic amide known for its polar solvent properties. This stable isotope serves as a valuable tracer in chemical research and analysis. It is extensively utilized in various applications, including the study of solvent-solute interactions, formulation development in pharmaceuticals, and the investigation of teratogenic effects in safety studies.

4-Iodoaniline-13C6 is a stable isotope-labeled derivative of 4-Iodoaniline, acting as a potent methemoglobin former. This compound serves as an important intermediate for the synthesis of glycogen phosphorylase inhibitors and is utilized in research focused on liver cancer and hematological disorders. The 13C labeling allows for enhanced tracking and analysis in various biochemical applications.

Phthalaldehyde-d6 is a deuterium-labeled derivative of phthalaldehyde, a key reagent utilized in biochemical assays. This compound selectively reacts with amino acids, enabling the derivatization and subsequent measurement of the resulting fluorescent products through high-performance liquid chromatography (HPLC). Its stable isotope labeling enhances the sensitivity and accuracy of analytical applications in biochemical studies and metabolic analysis.

4,4'-Sulfonyldiphenol-13C12 is a stable isotope-labeled variant of 4,4'-sulfonyldiphenol, commonly known as Bisphenol S. This compound serves as a useful biochemical reagent in life science research, facilitating studies related to endocrine disruption and polymer synthesis. Its incorporation of carbon-13 enables advanced analytical techniques such as NMR and mass spectrometry to trace metabolic pathways and environmental interactions of Bisphenol S in various biological systems.

5-Methyl-1H-benzotriazole-d6 is a deuterium-labeled derivative of 5-Methyl-1H-benzotriazole, serving as a stable isotope. This compound is valuable in life science research for applications such as tracing and quantifying metabolites in metabolic studies and aiding in the elucidation of biological pathways. Its unique labeling enhances the precision and accuracy of analytical techniques, making it an essential tool for chemical research.

Terephthalic acid-d4 is a deuterium-labeled derivative of terephthalic acid, primarily utilized as a stable isotope. This compound serves as a precursor in the synthesis of polyethylene terephthalate (PET), which is widely used in textile and plastic manufacturing. Terephthalic acid-d4 can also be employed in the development of skin tumor models, aiding in cancer research and therapeutic studies.

2-Naphthoic acid-13C6 is a stable isotope-labeled form of 2-Naphthoic acid, primarily utilized in chemical research for tracing and quantification applications. This compound serves as a versatile raw material for the synthesis of dyes and other organic chemicals, facilitating critical research in textile, printing, and manufacturing industries. Additionally, it is employed in the development of photosensitive materials and lubricants, contributing to advancements in material science and engineering.

MTSSL-15N,d15 is a deuterium and 15N-labeled variant of the reactive thiol-specific spin label MTSSL. This compound serves as an effective tool for labeling protein thiol residues, facilitating studies on protein structure, dynamics, and protein-protein interactions. Its stable isotope labeling enhances the precision of experimental results in biochemical and biophysical research applications.

1-Bromo-3-iodobenzene-d4 is a deuterated form of 1-Bromo-3-iodobenzene, serving as a stable isotope labeled biochemical reagent. This compound is valuable in organic synthesis, facilitating the formation of other active compounds. It is particularly useful in tracing studies and monitoring metabolic pathways in biochemical research.

5-Aminopyrimidine-d3 is a stable isotope of 5-Aminopyrimidine, a significant biochemical reagent widely used in life sciences research. This compound serves as a precursor for various derivatives that exhibit antioxidant activity. It is valuable for studying metabolic pathways and interactions in biochemical assays, enabling precise tracking in isotopic labeling experiments.

Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is a deuterated form of Ceramide 3, a bioactive sphingolipid notably present in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. With a phytosphingosine backbone linked to a C18 fatty acid chain, Ceramide 3-d3 plays a crucial role in regulating apoptosis and cell differentiation, while also supporting smooth muscle cell proliferation and inhibiting the mitochondrial respiratory chain. Furthermore, it suppresses the expression of pro-inflammatory cytokines IL-4 and TNF-α, as well as transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue, making it valuable for research in skin health and inflammation.

Benzene-1,3,5-tricarboxylic acid-d3 is a deuterated form of Benzene-1,3,5-tricarboxylic acid, commonly known as trimesic acid, serving as a stable isotope-labeled scaffold. This compound enhances the binding affinity of bicyclic peptides to target proteins and contributes to the mechanical stability of hydrogels. It is useful in various research applications, including synthetic biology, drug development, and biomaterials science, facilitating studies on protein interactions and material properties.

Methyl heptanoate-d13 is a deuterium-labeled stable isotope of Methyl heptanoate, primarily utilized in analytical chemistry and metabolic research. This compound serves as a valuable tracer in studies involving flavor and fragrance components, as well as in the analysis of solvent behavior with resins, oils, and waxes. Additionally, Methyl heptanoate-d13 has applications in biofuel research and polymer production, facilitating the investigation of metabolic pathways and product synthesis in various scientific fields.

Linolenic acid glycidyl ester-d5 is a deuterium-labeled derivative of linolenic acid glycidyl ester. This stable isotope compound can be utilized in various biochemical research applications, particularly in fatty acid metabolism studies and tracer experiments. Its unique labeling offers advantages in quantification and tracking of biological processes involving unsaturated fatty acids.

(S)-N-Methylpyrrolidine-2-methanol-d5 is a stable isotope-labeled version of (S)-N-Methylpyrrolidine-2-methanol, functioning as a biochemical reagent in life science research. This compound serves as a valuable tool for studying biological processes and interactions in various experimental settings. Its deuterium labeling enhances tracking capabilities and provides insights into molecular dynamics and mechanisms.

Borocaptate-10B12 sodium is a stable isotope-labeled boron-containing compound designed for use in boron neutron capture therapy (BNCT). It serves as an effective therapeutic agent, demonstrating notable anticancer activity through the selective delivery of boron-10 to tumor cells. Its application in research facilitates the exploration of BNCT's potential in cancer treatment, enhancing the understanding of targeted therapies.