IST-622 is an endogenous metabolite exhibiting significant anti-tumor activity through the inhibition of cancer cell growth. It demonstrates potent growth inhibitory effects against various mouse tumor models, including P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, and Colon 26 and 38 adenocarcinomas. Additionally, IST-622 is effective in human tumor xenograft models, notably large cell lung carcinoma and gastric adenocarcinoma. In vitro studies reveal an IC50 for P388 leukemia that is over 20 times lower than conventional treatments, underscoring its potential as a therapeutic agent in oncology research.
IST-622 is an endogenous metabolite exhibiting significant anti-tumor activity through the inhibition of cancer cell growth. It demonstrates potent growth inhibitory effects against various mouse tumor models, including P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, and Colon 26 and 38 adenocarcinomas. Additionally, IST-622 is effective in human tumor xenograft models, notably large cell lung carcinoma and gastric adenocarcinoma. In vitro studies reveal an IC50 for P388 leukemia that is over 20 times lower than conventional treatments, underscoring its potential as a therapeutic agent in oncology research.
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