JAK 3i is a highly selective inhibitor of JAK3, exhibiting an IC50 of 0.43 nM. It forms a covalent bond with a specific cysteine residue in the JAK3 kinase domain, demonstrating minimal interaction with JAK1, JAK2, or TYK2. JAK 3i effectively inhibits IL-2-driven T-cell proliferation in vivo, making it a valuable tool for research applications in autoimmune diseases and related therapeutic studies.
JAK 3i is a highly selective inhibitor of JAK3, exhibiting an IC50 of 0.43 nM. It forms a covalent bond with a specific cysteine residue in the JAK3 kinase domain, demonstrating minimal interaction with JAK1, JAK2, or TYK2. JAK 3i effectively inhibits IL-2-driven T-cell proliferation in vivo, making it a valuable tool for research applications in autoimmune diseases and related therapeutic studies.
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