Stat - STAT3

Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells.

SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3.

FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 uM.

Protosappanin A is an immunosuppressive ingredient of the medicinal herb Caesalpinia sappan L.