Documents & Downloads

(+)-JJ-450

AR Antagonist

(+) -JJ-450 is a non-competitive antagonist of the androgen receptor (AR), effectively inhibiting AR nuclear localization and transcriptional activity in the absence of androgen. This compound promotes the degradation of unliganded AR within the nucleus, thereby reducing the binding of AR to androgen response elements (AREs), including its splice variants like ARv7. With lower efficacy than its counterpart, (-)-JJ-450, in suppressing prostate-specific antigen (PSA) expression in LN95 cells, (+)-JJ-450 is particularly relevant for research focused on castration-resistant prostate cancer (CRPC) that exhibits resistance to enzalutamide.

Out of Stock

Free Aliquoting for Your Order

Tell us your preferred amount per vial. We’ll confirm the options.

Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1998094-24-8
Applications	AR Antagonist
Formula	C₂₁H₂₂ClFN₂O
Molecular Weight	372.86
SMILES	O=C([C@@H]1C[C@@H]1C2=CC=C(C=C2)F)N3CCN(CC3)C4=CC(Cl)=CC=C4C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.