JNJ-47965567 is a high-affinity, selective antagonist of the P2X7 receptor, exhibiting centrally permeable properties with pKis of 7.9 for human P2X7 and 8.7 for rat P2X7. This compound is instrumental in investigating the role of central P2X7 in rodent models, providing insights into its involvement in various CNS pathophysiological conditions. JNJ-47965567 is valuable for studies aimed at elucidating the molecular mechanisms underlying neurological disorders.
JNJ-47965567 is a high-affinity, selective antagonist of the P2X7 receptor, exhibiting centrally permeable properties with pKis of 7.9 for human P2X7 and 8.7 for rat P2X7. This compound is instrumental in investigating the role of central P2X7 in rodent models, providing insights into its involvement in various CNS pathophysiological conditions. JNJ-47965567 is valuable for studies aimed at elucidating the molecular mechanisms underlying neurological disorders.
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