JNJ-54166060 is a potent and selective antagonist of the P2X7 receptor, exhibiting IC50 values of 4 nM for the human, 115 nM for the rat, and 72 nM for the mouse P2X7 receptor. This compound modulates the purinergic signaling pathway, influencing processes such as inflammation and cell death. JNJ-54166060 is valuable for research applications related to autoimmune diseases, neuroinflammation, and other conditions where P2X7 receptor modulation is of interest.
JNJ-54166060 is a potent and selective antagonist of the P2X7 receptor, exhibiting IC50 values of 4 nM for the human, 115 nM for the rat, and 72 nM for the mouse P2X7 receptor. This compound modulates the purinergic signaling pathway, influencing processes such as inflammation and cell death. JNJ-54166060 is valuable for research applications related to autoimmune diseases, neuroinflammation, and other conditions where P2X7 receptor modulation is of interest.
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