JNJ-55308942 is a selective P2X7 antagonist with high affinity and significant brain penetration. It effectively inhibits the P2X7 receptor, demonstrating IC50 values of 10 nM for human and 15 nM for rat P2X7, along with corresponding Ki values of 7.1 nM and 2.9 nM. This compound is orally bioavailable and has been shown to block the release of IL-1β from adult rodent brain tissue, making it a valuable tool for investigating neuroinflammatory processes and related therapeutic applications.
JNJ-55308942 is a selective P2X7 antagonist with high affinity and significant brain penetration. It effectively inhibits the P2X7 receptor, demonstrating IC50 values of 10 nM for human and 15 nM for rat P2X7, along with corresponding Ki values of 7.1 nM and 2.9 nM. This compound is orally bioavailable and has been shown to block the release of IL-1β from adult rodent brain tissue, making it a valuable tool for investigating neuroinflammatory processes and related therapeutic applications.
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